Findings on liver biopsy to investigate abnormal liver function tests in the absence of diagnostic serology
| Autor: | Stephen D. Ryder, Maeve M. Skelly, Peter D. James |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
Liver Cirrhosis
Male medicine.medical_specialty Pathology Gastroenterology Primary sclerosing cholangitis Liver disease Liver Function Tests Internal medicine Biopsy medicine Glycogen storage disease Humans Serologic Tests Prospective Studies Hepatology medicine.diagnostic_test business.industry Liver Diseases Fatty liver Biopsy Needle medicine.disease Fatty Liver Liver Liver biopsy Abnormal Liver Function Test Female business Liver function tests Fatty Liver Alcoholic |
| Zdroj: | Journal of hepatology. 35(2) |
| ISSN: | 0168-8278 |
| Popis: | Background/Aims : The significance of abnormal liver function tests in the absence of diagnostic serology is unclear. The aim of this study was to report liver biopsy findings in a large group of patients with unexplained abnormal liver biochemistry. Methods : Histological findings were examined in 354 patients who underwent liver biopsy to investigate abnormal liver function tests. Results : Six percent of patients had a normal liver biopsy while 26% were found to have some degree of fibrosis and 6% were cirrhotic. Thirty four and 32% of biopsies suggested non-alcoholic steatohepatits or fatty liver respectively. Other diagnoses included cryptogenic hepatitis, drug toxicity, primary and secondary biliary cirrhosis, autoimmune hepatits, alcohol-related liver disease, primary sclerosing cholangitis, haemochromatosis, amyloid and glycogen storage disease. Patient management was directly altered in 18% of patients due to liver biopsy findings and three families were entered into screening programmes for inheritable liver disease. Conclusions : The finding of abnormal liver function tests in the absence of diagnostic serology may indicate significant liver disease. Liver biopsy yields a range of liver diseases of diverse nature and extent. Liver diseases may be uncovered for which specific treatment is indicated. |
| Databáze: | OpenAIRE |
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