The native form of follicle-stimulating hormone is essential for the growth of mouse preantral follicles in vitro
| Autor: | Min Hee Park, Keun Cheon Kim, Jeong Mook Lim, Jung Im Yun, Seung Tae Lee |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Infertility endocrine system Biology Tissue Culture Techniques Andrology Mice 03 medical and health sciences Follicle-stimulating hormone Follicle 0302 clinical medicine Endocrinology Ovarian Follicle medicine Animals 030219 obstetrics & reproductive medicine Metaphase ii Oocyte medicine.disease In vitro Protein Subunits 030104 developmental biology medicine.anatomical_structure Female Animal Science and Zoology Folliculogenesis Follicle Stimulating Hormone hormones hormone substitutes and hormone antagonists Developmental Biology Hormone |
| Zdroj: | Reproductive Biology. 21:100469 |
| ISSN: | 1642-431X |
| DOI: | 10.1016/j.repbio.2020.100469 |
| Popis: | To assess whether the follicle-stimulating hormone (FSH) subunits observed in patients with gonadotroph adenomas (GA) can cause infertility, the effects of subunits and heterodimeric FSH on the in vitro follicle development were evaluated in mice. The partial forms of FSH in follicle culture did not induce development into pseudoantral follicles, whereas follicles cultured with native FSH developed into pseudoantral follicles and produced mature metaphase II oocyte. Therefore, intact FSH is needed for folliculogenesis, implying that production of FSH with a partial structure in GA may result in infertility. |
| Databáze: | OpenAIRE |
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