Novel bioactive adhesive dressing based on gelatin/ chitosan cross-linked cactus mucilage for wound healing
| Autor: | Samira Jebahi, Bessaleh Salma, Amel Raouafi, Hajji Sawsen, Keskes Hassib, Mustpha Hidouri |
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| Rok vydání: | 2022 |
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| Zdroj: | The International Journal of Artificial Organs. 45:857-864 |
| ISSN: | 1724-6040 0391-3988 |
| Popis: | The development of natural-based wound dressings is of great interest in the field of skin tissue engineering. Herein, different bioactive molecules such as gelatin (GEL), chitosan (CH) and mucilage (MU) were used to prepare a wound dressing. The physico-chemical and biological characterizations occurring after γ-irradiation were investigated. Results showed that Electron Paramagnetic Resonance (EPR) spectroscopy of un-irradiated GEL-CH-MU biomaterial showed two paramagnetic centers which correspond to g = 1.89 and g = 2.033. A generated new active center appeared at g = 2.003 at 25 kGy due to the interactions of gamma rays with the polymer chain creating signals at the absorbing functional groups. X-ray diffraction (XRD) spectra preserved the semi-crystalline structures between a range of 2θ (5° and 45°). Fourier Transform Infrared spectroscopy (FTIR) revealed that the initiation of cross linking phenomena. Moreover, γ-rays significantly increased antioxidant activity (9.1 ± 0.07%, p |
| Databáze: | OpenAIRE |
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