Proton and carbon chemical shift assignment and dynamic investigation of the macrolide antibiotic tylosin

Autor:	Piero Corti, Maria Pia Picchi, Gianfranco Corbini, Claudio Rossi, Maria Rosaria Sansoni, Alessandro Donati
Rok vydání:	1992
Předmět:	Proton Stereochemistry Relaxation (NMR) Spectral properties chemistry.chemical_element Protonation General Chemistry Tylosin Spectral line chemistry.chemical_compound chemistry Computational chemistry Moiety General Materials Science Nuclear Experiment Carbon
Zdroj:	Magnetic Resonance in Chemistry. 30:954-957
ISSN:	1097-458X 0749-1581
DOI:	10.1002/mrc.1260301007
Popis:	The NMR spectral properties of the antibiotic tylosin were investigated. DQ-COSY and HETCOR two-dimensional spectra were used for the assignment of both the proton and protonated carbon signals. Selective (H)C-NOE, were proposed for the controversial quaternary carbon assignments. The analysis of molecular motion in solution based on carbon spin–lattice relaxation rates shows that tylosin exhibits dynamics that are typical of each molecular moiety. A higher degree of free motion is observed with increasing distance from the macrolide nucleus.
Databáze:	OpenAIRE
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