A feasibility randomised controlled trial of targeted oxygen therapy in mechanically ventilated critically ill patients
| Autor: | Margaret McNeil, Norman R. Williams, Andrew F. Cumpstey, Chris Brew-Graves, Michael P.W. Grocott, Ronan O’Driscoll, Jia Liu Stevens, Rachel Burnish, Michael G. Mythen, Daniel Martin, Helder Filipe |
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| Rok vydání: | 2021 |
| Předmět: |
Mechanical ventilation
medicine.medical_specialty Critically ill business.industry medicine.medical_treatment chemistry.chemical_element Original Articles Critical Care and Intensive Care Medicine Critical Care Nursing Oxygen law.invention 03 medical and health sciences 0302 clinical medicine Randomized controlled trial chemistry 030202 anesthesiology law Intensive care Oxygen therapy Critical illness medicine 030212 general & internal medicine Intensive care medicine business Oxygen saturation (medicine) |
| Zdroj: | J Intensive Care Soc |
| ISSN: | 1751-1437 |
| DOI: | 10.1177/17511437211010031 |
| Popis: | Background Despite oxygen being the commonest drug administered to critically ill patients we do not know which oxygen saturation (SpO2) target results in optimal survival outcomes in those receiving mechanical ventilation. We therefore conducted a feasibility randomised controlled trial in the United Kingdom (UK) to assess whether it would be possible to host a larger national multi-centre trial to evaluate oxygenation targets in mechanically ventilated patients. Methods We set out to recruit 60 participants across two sites into a trial in which they were randomised to receive conservative oxygenation (SpO2 88–92%) or usual care (control – SpO2 ≥96%). The primary outcome was feasibility; factors related to safety and clinical outcomes were also assessed. Results A total of 34 patients were recruited into the study until it was stopped due to time constraints. A number of key barriers to success were identified during the course of the study. The conservative oxygenation intervention was feasible and appeared to be safe in this small patient cohort and it achieved wide separation of the median time-weighted average (IQR) SpO2 at 91% (90–92%) in conservative oxygenation group versus 97% (96–97%) in control group. Conclusion Whilst conservative oxygenation was a feasible and safe intervention which achieved clear group separation in oxygenation levels, the model used in this trial will require alterations to improve future participant recruitment rates in the UK. |
| Databáze: | OpenAIRE |
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