Towards hydroxylated nylon 6: linear and cyclic oligomers from a protected 6-amino-6-deoxy-D-galactonate - a novel class of carbopeptoid-cyclodextrin (CPCD)

Autor:	Alison A. Edwards, George E. Tranter, Benjamin Alexander Mayes, George W. J. Fleet, Mark P. Watterson, Christopher W. G. Ansell, Rebecca J. E. Stetz
Jazyk:	angličtina
Rok vydání:	2016
Předmět:	chemistry.chemical_classification Circular dichroism Cyclodextrin Stereochemistry Organic Chemistry Diastereomer Catalysis Cyclic peptide Amino acid Inorganic Chemistry chemistry.chemical_compound chemistry Tetramer Lactam QD Physical and Theoretical Chemistry Protein secondary structure
ISSN:	0957-4166
Popis:	Circular dichroism studies on a series of linear oligomers derived from a protected 6-amino-6-deoxy-D-galactonate (an ε-amino acid) indicated a predisposition to form a rigid structure in solution, which is comparable to a β-sheet composed of L-amino acids; in contrast, a diastereomeric allonate series provided no evidence for secondary structure. A linear tetramer was cyclised to a 28-membered ring lactam in modest yield, which on deprotection formed a class of macrocycle with structural features of both a cyclic peptide and a cyclodextrin. © 2004 Elsevier Ltd. All rights reserved.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0477b7f827f1f443bc43489c885655a8 https://ora.ox.ac.uk/objects/uuid:801e6113-e26a-4fb1-a2dd-c47ab6ff3767 Zobrazit plný text záznamu Full Text from ScienceDirect