fMRI fingerprint of unconditioned fear-like behavior in rats exposed to trimethylthiazoline
| Autor: | Markus von Kienlin, Basil Künnecke, Sebastien Debilly, Melanie S. Keßler, Joseph G. Wettstein, Thomas Bielser, Stephanie Schöppenthau, Celine Risterucci, Andreas Bruns, Jean-Luc Moreau |
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| Rok vydání: | 2010 |
| Předmět: |
Nucleus accumbens
Periaqueductal gray Ventral pallidum medicine Premovement neuronal activity Animals Pharmacology (medical) Rats Wistar Freezing Reaction Cataleptic Biological Psychiatry Pharmacology Fear processing in the brain Neurons medicine.diagnostic_test Behavior Animal Brain Fear Magnetic Resonance Imaging Rats Ventral tegmental area Psychiatry and Mental health Freezing behavior Thiazoles medicine.anatomical_structure nervous system Neurology Odorants Neurology (clinical) Functional magnetic resonance imaging Psychology Neuroscience |
| Zdroj: | European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. 22(3) |
| ISSN: | 1873-7862 |
| Popis: | Unconditioned fear plays an important yet poorly understood role in anxiety disorders, and only few neuroimaging studies have focused on evaluating the underlying neuronal mechanisms. In rodents the predator odor trimethylthiazoline (TMT), a synthetic component of fox feces, is commonly used to induce states of unconditioned fear. In this study, arterial spin labeling-based functional magnetic resonance imaging (fMRI) was applied to detect TMT-induced regional modulations of neuronal activity in Wistar rats. During TMT exposure the rats displayed increased freezing behavior and reduced exploration in the odor-associated area. Neuronal activity was selectively increased in the dorsal periaqueductal gray, superior colliculus and medial thalamus and reduced in the median raphe, locus coeruleus, nucleus accumbens shell, ventral tegmental area, ventral pallidum and entorhinal piriform cortex. This fMRI fingerprint involving distinct neuronal pathways was used to describe a schematic model of fear processing. Key brain areas known to underlie fear and anxiety-related autonomic and behavioral responses as well as centers of motivational processing were identified as being part of this functional circuitry of innate fear. Thus, preclinical fMRI studies based on unconditioned fear methods may provide a valuable translational approach to better characterize etiological and pathological processes underlying anxiety disorders. |
| Databáze: | OpenAIRE |
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