The association between the vaginal microenvironment and fecundability: a register-based cohort study among Chinese women
| Autor: | Bei Wang, Qiaomei Wang, Hongguang Zhang, Jiechen Yin, Haiping Shen, Xu Ma, Yan Xuan, Donghai Yan, Xiaoyue Zhu, Zuoqi Peng, Yuanyuan Wang, Ya Zhang, Jun Zhao, Shenghao Fang, Xiang Hong, Yiping Zhang, Xueying Yang, Yue Zhang, Qiaoyun Dai |
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| Rok vydání: | 2021 |
| Předmět: |
Adult
medicine.medical_specialty China Population Cohort Studies Young Adult Asian People Pregnancy Ethnicity Medicine Humans Registries education education.field_of_study business.industry Obstetrics Obstetrics and Gynecology Prenatal Care Odds ratio medicine.disease Irregular menstruation Fertility Propensity score matching Vagina Population study Female medicine.symptom business Clue cell Cohort study |
| Zdroj: | BJOG : an international journal of obstetrics and gynaecologyReferences. 129(1) |
| ISSN: | 1471-0528 |
| Popis: | OBJECTIVE To evaluate the association between the vaginal microenvironment and fecundability among women. DESIGN Register-based nationwide cohort study. SETTING Chinese National Free Pre-conception Check-up Project from 2015 to 2018. POPULATION Our study included a total of 3 388 554 eligible women who were attempting to become pregnant. METHOD We assessed the vaginal microenvironment at baseline by considering four indices: vaginal pH, clue cell examination, whiff test and vaginal cleanliness grading. If any of these indicators was abnormal, the vaginal microenvironment was defined as poor. Propensity score matching was used to control for potential confounders and reduce bias. Logistic models were used to estimate the fecundability odds ratios (FORs) after adjustment for covariates. MAIN OUTCOME MEASURES Achievement of a pregnancy within 1 year. RESULTS Of the total study population, 379 718 women (11.2%) had a poor vaginal microenvironment and their pregnancy rate after 1 year was significantly lower than the group with a normal microenvironment (71.8% versus 76.1%, P |
| Databáze: | OpenAIRE |
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