Torsade de pointes due to noncardiac drugs: most patients have easily identifiable risk factors
| Autor: | Vitaly Prokhorov, Amir Halkin, Karin Heller, Sami Viskin, David Zeltser, Dan Justo |
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| Rok vydání: | 2003 |
| Předmět: |
Drug
Male medicine.medical_specialty Heart disease media_common.quotation_subject Long QT syndrome Culprit QT interval Risk Factors Torsades de Pointes Internal medicine Medicine Humans Medical history Risk factor Sex Distribution media_common business.industry General Medicine medicine.disease Anti-Bacterial Agents Anesthesia Histamine H1 Antagonists Female business Complication Antipsychotic Agents |
| Zdroj: | Medicine. 82(4) |
| ISSN: | 0025-7974 |
| Popis: | Numerous medications, including drugs prescribed for noncardiac indications, can lead to QT prolongation and trigger torsade de pointes. Although this complication occurs only rarely, it may have lethal consequences. It is therefore important to know if patients with torsade de pointes associated with noncardiac drugs have risk factors that are easy to identify. We reviewed reports of drug-induced torsade de pointes and analyzed each case of torsade de pointes associated with a noncardiac drug for the presence of risk factors for the long QT syndrome that can be easily identified from the medical history or clinical evaluation (female gender, heart disease, electrolyte disturbances, excessive dosing, drug interactions, and history of familial long QT syndrome). We identified 249 patients with torsade de pointes caused by noncardiac drugs. The most commonly identified risk factor was female gender (71%). Other risk factors were frequently present (18%-41%). Virtually all patients had at least 1 of these risk factors, and 71% of patients had 2 or more risk factors. Our study suggests that almost all patients with torsade de pointes secondary to noncardiac drugs have risk factors that can be easily identified from the medical history before the initiation of therapy with the culprit drug. |
| Databáze: | OpenAIRE |
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