Antiinflammatory agents. 1. Synthesis and antiinflammatory activity of 2-amino-3-benzoylphenylacetic acid

Autor:	Moran Hw, H. F. Stauffer, L. F. Sancilio, William J. Welstead, Turnbull Lb
Rok vydání:	1979
Předmět:	Male Stereochemistry Chemistry Anti-Inflammatory Agents Metabolism Ethyl ester In Vitro Techniques Arthritis Experimental Sodium salt Rats Pleural Effusion Benzophenones Drug Discovery Molecular Medicine Animals Female Active metabolite Biotransformation Phenylacetates
Zdroj:	Journal of medicinal chemistry. 22(9)
ISSN:	0022-2623
Popis:	The synthesis and antiinflammatory activity of 2-amino-3-benzoylphenylacetic acid are described. This compound was postulated to be an active metabolite of 7-benzoylindoline in order to explain the unexpected antiinflammatory activity of the latter compound. Metabolism studies on 14C-labeled 7-benzoylindoline did not confirm this hypothesis. Nevertheless, 2-amino-3-benzoylphenylacetic acid, its ethyl ester, and the sodium salt show potent antiinflammatory activity in pharmacological models.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0473728450e0ea58904d0fe1e0b9a1e7 https://pubmed.ncbi.nlm.nih.gov/490552 Zobrazit plný text záznamu