Effect of metabolic syndrome on neural plasticity and morphology of the hippocampus: correlations of neurological deficits with physiological status of the rat
| Autor: | Boris Lipták, Zdenka Gasparova, Barbara Kaprinay, Ruzena Sotnikova, Hisham El Falougy, Weismann P, Pavol Janega, Dominika Michalikova |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Physiology Long-Term Potentiation Biophysics Hippocampus Carotid Intima-Media Thickness 03 medical and health sciences 0302 clinical medicine Insulin resistance Internal medicine medicine Animals Rats Wistar Metabolic Syndrome Neuronal Plasticity business.industry Fatty liver Long-term potentiation General Medicine medicine.disease Rats 030104 developmental biology Endocrinology Synaptic plasticity Metabolic syndrome Steatosis business 030217 neurology & neurosurgery Dyslipidemia |
| Zdroj: | General physiology and biophysics. 37:619-632 |
| ISSN: | 1338-4325 |
| DOI: | 10.4149/gpb_2018016 |
| Popis: | Fat-rich diet (FRD) triggers health complications like hypertension, dyslipidemia, hyperglycemia, insulin resistance and non-alcoholic fatty liver disease, known as the risk factors of metabolic syndrome (MetS), which may result in neurological deficits. The impact of MetS on neuronal functions and brain morphology are poorly understood. We induced MetS-like conditions by exposing hypertriacylglycerolemic (HTG) rats to FRD for eight weeks with the aim to study possible neurological dysfunctions. HTG-FRD rats were compared to HTG rats and Wistar rats on standard diet. The physiological status of the animals was monitored by body, liver and kidney weight. Morphology of the liver, vessel wall and hippocampus were investigated. Basal neurotransmission and synaptic plasticity were measured in the hippocampus ex-vivo. A marked increase of liver weight with marks of steatosis was found in the HTG-FRD group. FRD induced an increase of aortic intima-media thickness. Extracellular recording revealed FRD-induced impairment of long-term potentiation (LTP) at Cornu Ammonis (CA)3-CA1 synapse, contrary to increased presynaptic fiber volley (pV). Reduced thickness of pyramidal cell layer at the CA1 area was found morphometrically. LTP was directly associated with kidney weight and inversely associated with liver weight, pV directly correlated with liver weight, liver/body wt ratio and aortic intima-media thickness. Our results suggest correlations between altered physiological status due to MetS-like conditions and neurological deficits, which may be related with consecutive development of so-called metabolic cognitive syndrome. |
| Databáze: | OpenAIRE |
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