Alpha- and beta-adrenergic receptor (AR) protein expression is associated with poor clinical outcome in breast cancer: an immunohistochemical study
| Autor: | Kurt S. Zänker, Ian O. Ellis, Melanie J Voss, Hany Onsy Habashy, Des G. Powe, Frank Entschladen, Andrew R. Green |
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| Rok vydání: | 2011 |
| Předmět: |
Adult
Oncology Cancer Research medicine.medical_specialty medicine.medical_treatment Breast Neoplasms Kaplan-Meier Estimate Disease-Free Survival Metastasis Targeted therapy Breast cancer Receptors Adrenergic alpha-2 Receptors Adrenergic alpha-1 Internal medicine Biomarkers Tumor Adrenergic antagonist medicine Humans Lymph node Tissue microarray business.industry Carcinoma Ductal Breast Middle Aged Prognosis medicine.disease Immunohistochemistry Tumor Burden Carcinoma Lobular Endocrinology medicine.anatomical_structure Receptors Estrogen Hormonal therapy Female Receptors Adrenergic beta-2 Neoplasm Grading business |
| Zdroj: | Breast Cancer Research and Treatment. 130:457-463 |
| ISSN: | 1573-7217 0167-6806 |
| DOI: | 10.1007/s10549-011-1371-z |
| Popis: | Breast cancer mortality is frequently associated with metastatic disease. Metastasis models have shown adrenoceptor (AR) stimulation induces cell migration which is inhibited by adrenoceptor antagonist drugs. We investigated adrenoceptor protein expression in clinical breast tumours and its association with disease progression and prognosis. Immunohistochemistry on tissue microarrays was used to characterise α1b, α2c and β22 adrenoceptor protein expression in operable breast tumours. Associations with tumour-relevant biological markers and clinical outcome were statistically assessed. Strong α1b expression occurred in large high grade (P |
| Databáze: | OpenAIRE |
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