Acetic acid enhances endurance capacity of exercise-trained mice by increasing skeletal muscle oxidative properties
| Autor: | Jun Ho Kim, Dong-Hoon Shin, Eui Seop Lee, Minkyeong Shin, Hyung Min Kim, Young Jun Kim, Jin Hyup Lee, Seongpil Kim, Jeong Hoon Pan, Sang-Ho Kim |
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| Rok vydání: | 2015 |
| Předmět: |
medicine.medical_specialty
Oxidative phosphorylation Applied Microbiology and Biotechnology Biochemistry Analytical Chemistry Acetic acid chemistry.chemical_compound Mice Endurance training Internal medicine Physical Conditioning Animal medicine Animals Muscle Skeletal Molecular Biology Beta oxidation Acetic Acid chemistry.chemical_classification Glycogen Organic Chemistry Fatty acid Skeletal muscle General Medicine Lipid Metabolism Enzyme Endocrinology medicine.anatomical_structure chemistry Adipose Tissue Physical Endurance Oxidation-Reduction Biotechnology |
| Zdroj: | Bioscience, biotechnology, and biochemistry. 79(9) |
| ISSN: | 1347-6947 |
| Popis: | Acetic acid has been shown to promote glycogen replenishment in skeletal muscle during exercise training. In this study, we investigated the effects of acetic acid on endurance capacity and muscle oxidative metabolism in the exercise training using in vivo mice model. In exercised mice, acetic acid induced a significant increase in endurance capacity accompanying a reduction in visceral adipose depots. Serum levels of non-esterified fatty acid and urea nitrogen were significantly lower in acetic acid-fed mice in the exercised mice. Importantly, in the mice, acetic acid significantly increased the muscle expression of key enzymes involved in fatty acid oxidation and glycolytic-to-oxidative fiber-type transformation. Taken together, these findings suggest that acetic acid improves endurance exercise capacity by promoting muscle oxidative properties, in part through the AMPK-mediated fatty acid oxidation and provide an important basis for the application of acetic acid as a major component of novel ergogenic aids. |
| Databáze: | OpenAIRE |
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