Covalently antibacterial alginate-chitosan hydrogel dressing integrated gelatin microspheres containing tetracycline hydrochloride for wound healing
| Autor: | Yong Chen, Xiaohong Hu, Huaping Tan, Huinan Chen, Zhonghua Ling, Yang Jia, Xiaodong Xing, Tianle Zhou |
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| Rok vydání: | 2017 |
| Předmět: |
Time Factors
Materials science Compressive Strength Alginates Surface Properties Composite number Bioengineering Microbial Sensitivity Tests 02 engineering and technology Bacterial growth 010402 general chemistry 01 natural sciences Hydrogel Polyethylene Glycol Dimethacrylate Biomaterials Tetracycline Hydrochloride Glucuronic Acid Elastic Modulus Spectroscopy Fourier Transform Infrared medicine Composite material Chitosan Wound Healing Bacteria Hexuronic Acids Tetracycline 021001 nanoscience & nanotechnology Bandages Microspheres Anti-Bacterial Agents 0104 chemical sciences Kinetics Freeze Drying Mechanics of Materials Emulsion Drug delivery Self-healing hydrogels Gelatin Stress Mechanical Swelling medicine.symptom Rheology 0210 nano-technology Wound healing Nuclear chemistry |
| Zdroj: | Materials Science and Engineering: C. 70:287-295 |
| ISSN: | 0928-4931 |
| DOI: | 10.1016/j.msec.2016.08.086 |
| Popis: | An antibacterial and biodegradable composite hydrogel dressing integrated with microspheres is developed for drug delivery and wound healing. The mechanism of gelation is attributed to the Schiff-base reaction between aldehyde and amino groups of oxidized alginate (OAlg) and carboxymethyl chitosan (CMCS). To enhance antibacterial and mechanical properties, tetracycline hydrochloride (TH) loaded gelatin microspheres (GMs) were fabricated by an emulsion cross-linking method, followed by integrating into the OAlg-CMCS hydrogel to produce a composite gel dressing. In vitro gelation time, swelling, degradation, compressive modulus and rheological properties of the gel dressing were investigated as the function of microsphere ratios. With increasing ratios of microspheres from 10 to 40mg/mL, the composite dressing manifested shorter gelation time and lower swelling ratios, as well as higher mechanical strength. Comparing to other formulations, the gel dressing with 30mg/mL microspheres showed more suitable stabilities and mechanical properties for wound healing. Also, in vitro drug release results showed that the loaded TH could be sustained release from the composite gel dressing by contrast with pure hydrogels and microspheres. Furthermore, powerful bacteria growth inhibition effects against Escherichia coli and Staphylococcus aureus suggested that the composite gel dressing, especially the one with 30mg/mL GMs containing TH, has a promising future in treatment of bacterial infection. |
| Databáze: | OpenAIRE |
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