EFFECT OF SELENIUM SUPPLEMENTATION ON PROTEOMIC SERUM BIOMARKERS IN ELDERLY MEN
| Autor: | Steven P. Stratton, Patricia A. Thompson, Amit M. Algotar, Chiu Hsieh Hsu, Roxanna Behnejad, Parminder Singh |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
medicine.medical_specialty
Proteomic Profile Apolipoprotein B biology business.industry chemistry.chemical_element Cancer Phases of clinical research General Medicine Placebo Bioinformatics medicine.disease Gastroenterology Article Prostate cancer medicine.anatomical_structure chemistry Prostate Internal medicine medicine biology.protein business Selenium |
| Zdroj: | Journal of Frailty & Aging. :1-4 |
| ISSN: | 2273-4309 |
| DOI: | 10.14283/jfa.2015.48 |
| Popis: | Objectives: To determine the effect of selenium supplementation on the human proteomic profile. Design: Serum samples were collected in this pilot study from a randomized placebo controlled Phase 2 Watchful Waiting (WW) clinical trial. Setting: Subjects were followed every three months for up to five years at the University of Arizona Prostate Cancer Prevention Program Clinic. Participants: One hundred and forty men (age < 85 years) had biopsy-proven prostate cancer, a Gleason sum score less than eight, no metastatic cancer, and no prior treatment for prostate cancer. Intervention: As part of the WW trial, men were randomized to placebo, selenium 200 μg/day or selenium 800 μg/day. For the purpose of the current study, 40 subjects enrolled in the WW study (20 from the placebo group and 20 from Se 800 μg/day group) were selected. Measurements: Baseline serum samples were collected at each follow-up visit and stored at -80 degrees Celsius. A multiplexed proteomic panel investigated changes in 120 proteins markers simultaneously. Results: Thirteen proteins (Apolipoprotein J, IL-10, IL-1 alpha, MMP-3, IL-12p70, IL-2 receptor alpha, cathepsin B, eotaxin, EGFR, FGF-basic, myeloperoxidase, RANTES, TGF-beta) were determined to be either statistically (p-value < 0.05) or marginally significantly (0.05 < p-value |
| Databáze: | OpenAIRE |
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