Axonal injury in experimental herpes simplex encephalitis
| Autor: | Yoshinobu Kimura, Yoshinori Imai, Fumi Goshima, Shinichi Kohsaka, Isamu Mori, Hiroyasu Ito, Naoki Koide, Takashi Yokochi, Terukazu Mizuno, Tomoaki Yoshida, Yukihiro Nishiyama |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
Apoptosis
medicine.disease_cause Amyloid beta-Protein Precursor Mice Immunolabeling Alphaherpesvirinae medicine Amyloid precursor protein Animals Axon Molecular Biology Mice Inbred BALB C biology Microglia General Neuroscience Calcium-Binding Proteins Microfilament Proteins medicine.disease biology.organism_classification Immunohistochemistry Virology Axons Herpes simplex virus medicine.anatomical_structure nervous system biology.protein Neuroglia Encephalitis Herpes Simplex Neurology (clinical) Encephalitis Developmental Biology |
| Zdroj: | Brain Research. 1057:186-190 |
| ISSN: | 0006-8993 |
| DOI: | 10.1016/j.brainres.2005.07.037 |
| Popis: | Using β-amyloid precursor protein immunolabeling, we have detected axonal injury in experimental herpes simplex encephalitis. β-amyloid precursor protein-specific signals were found in the mouse brain as either puncta or axon-like structures. They appeared where infected neurons were undergoing apoptosis and Iba1-immunopositive microglia transformed themselves into macrophages. These results show, for the first time, that axonal injury, i.e., functional disturbance of the fast axonal transport, can take place during the course of acute viral encephalitis. |
| Databáze: | OpenAIRE |
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