Lipoprotein-induced inhibition of plaque-forming cell generation and natural killer cell frequency in aged donors
| Autor: | Lorenzo Bonomo, Salvatore Antonaci, Emilio Jirillo, Maria Teresa Ventura, Garofalo Ar |
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| Rok vydání: | 1984 |
| Předmět: |
Chromium
Cytotoxicity Immunologic Male Aging Lipoproteins Cell Hemolytic Plaque Technique In Vitro Techniques Biology Peripheral blood mononuclear cell Monocytes Natural killer cell medicine Humans Cytotoxic T cell Lymphocytes Antibody-Producing Cells Cytotoxicity Aged General Environmental Science Lymphokine-activated killer cell General Medicine Natural killer T cell Molecular biology Killer Cells Natural medicine.anatomical_structure Immunology General Earth and Planetary Sciences Female Lipoprotein |
| Zdroj: | Annales de l'Institut Pasteur / Immunologie. 135:241-249 |
| ISSN: | 0769-2625 |
| Popis: | Summary The in vitro effects of human high-density, low-density and very-low-density lipoproteins on plaque-forming cell generation and natural killer cytotoxicity were evaluated in 40 aged donors. Lipoprotein pretreatment led to a significant inhibition in plaqueforming cell capacity displayed by either peripheral blood mononuclear cells or purified lymphocytes. As far as natural killer cytotoxicity is concerned. such pretreatment decreased the number of natural killer cells bound to targets, while the lytic efficiency was unaffected in both 51Cr-release and agarose-single-cell cytotoxic assays. These data suggest a role for lipoproteins in the impairment of cell-mediated immunity in elderly individuals. |
| Databáze: | OpenAIRE |
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