Diagnostic Performance of [^{11}C]Methionine Positron Emission Tomography in Newly Diagnosed and Untreated Glioma Based on the Revised World Health Organization 2016 Classification
| Autor: | Toshiyuki Kawashima, Kenichi Ishibashi, Naohiro Tsuyuguchi, Takehiro Uda, Yuta Tanoue, Hiroshi Uda, Takeo Goto, Atsufumi Nagahama, Yuzo Terakawa, Kosuke Nakajo, Tsuyoshi Sasaki, Saya Koh, Yonehiro Kanemura, Kenji Ohata |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
IDH
Pathology medicine.medical_specialty World health Lesion 03 medical and health sciences chemistry.chemical_compound [^{11}C]methionine 0302 clinical medicine Glioma medicine Telomerase reverse transcriptase L/N ratio Methionine medicine.diagnostic_test business.industry medicine.disease Isocitrate dehydrogenase PET chemistry Positron emission tomography 030220 oncology & carcinogenesis TERT promoter Surgery Neurology (clinical) medicine.symptom business 030217 neurology & neurosurgery Anaplastic astrocytoma |
| Zdroj: | World Neurosurgery. 148:e471-e481 |
| ISSN: | 1878-8750 |
| Popis: | Background The relationship between uptake of amino acid tracer with positron emission tomography (PET) and glioma subtypes/gene status is still unclear. Objective To assess the relationship between uptake of [11C]methionine using PET and pathology, IDH (isocitrate dehydrogenase) mutation, 1p/19q codeletion, and TERT (telomerase reverse transcriptase) promoter status in gliomas. Methods The participants were 68 patients with newly diagnosed and untreated glioma who underwent surgical excision and preoperative [11C]methionine PET examination at Osaka City University Hospital between July 2011 and March 2018. Clinical and imaging studies were reviewed retrospectively based on the medical records at our institution. Results The mean lesion/contralateral normal brain tissue (L/N) ratio of diffuse astrocytomas was significantly lower than that of anaplastic astrocytomas (P = 0.00155), glioblastoma (P Conclusions Distinguishing glioma subtypes based on the revised 2016 World Health Organization classification of the central nervous system tumors on the basis of [11C]methionine PET alone seems to be difficult. However, [11C]methionine PET might be useful for predicting the IDH mutation status in newly diagnosed and untreated gliomas noninvasively before tumor resection. |
| Databáze: | OpenAIRE |
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