Analysis of Hand Joint Space Morphology in Women and Men with Hereditary Hemochromatosis
| Autor: | Ursula Heilmeier, Andrew J. Burghardt, Justin J. Tse, Puneet Kapoor, Kathryn S. Stok, Sarah Manske, Reinhard E. Voll, Georg Schett, Stephanie Finzel |
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| Rok vydání: | 2023 |
| Předmět: |
Male
Hand Joints Endocrinology Diabetes and Metabolism Clinical Sciences High-resolution peripheral computed tomography Biomedical Engineering Bioengineering Hemochromatosis arthropathy X-Ray Computed Metacarpophalangeal Joint Endocrinology & Metabolism Endocrinology Joint space Hereditary hemochromatosis Humans Biomedical Imaging Female Orthopedics and Sports Medicine Hemochromatosis Biochemistry and Cell Biology Tomography Algorithms |
| Zdroj: | Calcified tissue international, vol 112, iss 4 |
| ISSN: | 1432-0827 |
| Popis: | Hereditary hemochromatosis (HH) causes unbalanced iron deposition in many organs including the joints leading to severe cartilage loss and bone damage in the metacarpophalangeal joints (MCPJ). High-resolution peripheral quantitative computed tomography (HR-pQCT) and its joint space width (JSW) quantification algorithm quantifies in vivo 3D joint morphology. We therefore aimed to (i) determine feasibility and performance of the JSW algorithm in HH, (ii) quantify joint space morphology, and (iii) investigate the relationship between morphological and clinical parameters in HH. Here, we performed an exploratory study on 24 HH patients and sex- and age-matched controls using HR-pQCT imaging of MCPJ. Mineralized bone structure was automatically segmented from the grayscale image data and periosteal surface bone masks and joint space masks were generated. Mean, minimal, and maximal joint space width (JSW; JSW.MIN; JSW.MAX), JSW heterogeneity (JSW.SD), JSW asymmetry (JSW.AS), and joint space volume (JSV) were computed. Demographics and, for HH patients, disease-specific parameters were recorded. Segmentation of JS was very good with 79.7% of MCPJs successfully segmented at first attempt and 20.3% requiring semi-manual correction. HH men showed larger JSV at all MCPs (+ 25.4% p p p = 0.043) at MCP 4 relative to HH women. Compared to controls, both HH men and HH women showed larger JSW.AS and smaller JSW.MIN at all MCP levels, reaching significance for HH men at MCP 2 and 3 (JSW.AS: + 323% p p p = 0.025; JSW.MIN: − 41.8%, p = 0.022). Time since HH diagnosis was correlated positively with MCP 4 JSW.AS and JSW.SD (0.463 ρ p ρ p |
| Databáze: | OpenAIRE |
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