Factors affecting the susceptibility of the mouse pituitary gland to CD8 T-cell-mediated autoimmunity
| Autor: | James de Jersey, Danielle Carmignac, Brigitta Stockinger, Iain C. A. F. Robinson, Thomas Barthlott, Paul Le Tissier |
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| Rok vydání: | 2004 |
| Předmět: |
Pituitary gland
Hypophysitis CD8 Antigens Pituitary Diseases Immunology Radioimmunoassay Receptors Antigen T-Cell Context (language use) Autoimmunity Mice Transgenic Biology CD8-Positive T-Lymphocytes medicine.disease_cause Growth hormone deficiency Epitopes Mice Antigen Orthomyxoviridae Infections Pituitary Gland Anterior medicine Immunology and Allergy Cytotoxic T cell Endocrine system Animals Reverse Transcriptase Polymerase Chain Reaction Viral Core Proteins RNA-Binding Proteins Nucleocapsid Proteins medicine.disease Mice Inbred C57BL medicine.anatomical_structure Nucleoproteins Phenotype Growth Hormone Fast Track |
| Zdroj: | Immunology. 111(3) |
| ISSN: | 0019-2805 |
| Popis: | We have previously shown, in a transgenic mouse model, that the pituitary gland is susceptible to CD8 T-cell-mediated autoimmunity, triggered by a cell-specific model autoantigen, resulting in pan-anterior pituitary hypophysitis and dwarfism. In the present study, we now demonstrate that antigen dose, the T-cell precursor frequency, the degree of lymphopenia and the context of target antigen expression, are important parameters determining the time course and extent of the pathological consequences of CD8 T-cell-mediated autoimmunity. Furthermore, our data indicate that the pituitary gland is susceptible to CD8 autoimmunity following an inflammatory insult such as a viral infection. As lymphocytic hypophysitis may be manifest in other autoimmune conditions, and the pituitary gland may be susceptible to T-cell-mediated pathology after immunization with a virus expressing soluble pituitary antigen, it is important to consider that strategies based on vaccination against soluble pituitary gonadotrophins could have other unexpected endocrine consequences. |
| Databáze: | OpenAIRE |
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