Increased decision thresholds enhance information gathering performance in juvenile Obsessive-Compulsive Disorder (OCD)
| Autor: | Hauser, Tobias U, Moutoussis, Michael, Iannaccone, Reto, Brem, Silvia, Walitza, Susanne, Drechsler, Renate, Dayan, Peter, Dolan, Raymond J |
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| Přispěvatelé: | University of Zurich, Hauser, Tobias U |
| Rok vydání: | 2016 |
| Předmět: |
Male
Obsessive-Compulsive Disorder 2804 Cellular and Molecular Neuroscience Social Sciences Neuropsychological Tests Adolescents Cognition Medicine and Health Sciences Psychology Biology (General) 10064 Neuroscience Center Zurich 10058 Department of Child and Adolescent Psychiatry Anxiety Disorders Neurology 10076 Center for Integrative Human Physiology Physical Sciences Female Research Article Adolescent Patients QH301-705.5 Permutation Decision Making 610 Medicine & health Neuropsychiatric Disorders Neuroses Risk-Taking 1311 Genetics Developmental Neuroscience Mental Health and Psychiatry 1312 Molecular Biology Humans Behavior Models Statistical Behavioral Disorders Discrete Mathematics Cognitive Psychology Biology and Life Sciences Bayes Theorem Health Care 1105 Ecology Evolution Behavior and Systematics Age Groups Neurodevelopmental Disorders Combinatorics People and Places Cognitive Science Population Groupings Adhd 2303 Ecology Mathematics 2611 Modeling and Simulation 1703 Computational Theory and Mathematics Neuroscience |
| Zdroj: | PLoS Computational Biology PLoS Computational Biology, 13 (4) PLoS Computational Biology, Vol 13, Iss 4, p e1005440 (2017) |
| ISSN: | 1553-7358 1553-734X |
| Popis: | Patients with obsessive-compulsive disorder (OCD) can be described as cautious and hesitant, manifesting an excessive indecisiveness that hinders efficient decision making. However, excess caution in decision making may also lead to better performance in specific situations where the cost of extended deliberation is small. We compared 16 juvenile OCD patients with 16 matched healthy controls whilst they performed a sequential information gathering task under different external cost conditions. We found that patients with OCD outperformed healthy controls, winning significantly more points. The groups also differed in the number of draws required prior to committing to a decision, but not in decision accuracy. A novel Bayesian computational model revealed that subjective sampling costs arose as a non-linear function of sampling, closely resembling an escalating urgency signal. Group difference in performance was best explained by a later emergence of these subjective costs in the OCD group, also evident in an increased decision threshold. Our findings present a novel computational model and suggest that enhanced information gathering in OCD can be accounted for by a higher decision threshold arising out of an altered perception of costs that, in some specific contexts, may be advantageous. PLoS Computational Biology, 13 (4) ISSN:1553-734X ISSN:1553-7358 |
| Databáze: | OpenAIRE |
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