Cytomegalovirus Hijacks CX3CR1hi Patrolling Monocytes as Immune-Privileged Vehicles for Dissemination in Mice
| Autor: | Grace M. Wynn, Edward S. Mocarski, Linda Roback, Lisa P. Daley-Bauer |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Cancer Research
Muromegalovirus Chemokine CX3C Chemokine Receptor 1 Congenital cytomegalovirus infection Microbiology Monocytes Salivary Glands Article Virus Immunophenotyping Mice Viral Proteins Immune system Immunology and Microbiology(all) Virology CX3CR1 medicine Animals Molecular Biology biology Monocyte biology.organism_classification medicine.disease Mice Inbred C57BL Disease Models Animal medicine.anatomical_structure Chemokines CC Cytomegalovirus Infections Immunology biology.protein Receptors Chemokine Parasitology |
| Zdroj: | Cell Host & Microbe. 15:351-362 |
| ISSN: | 1931-3128 |
| DOI: | 10.1016/j.chom.2014.02.002 |
| Popis: | Summary Peripheral blood myelomonocytic cells are important for cytomegalovirus dissemination to distal organs such as salivary glands where persistent replication and shedding dictates transmission patterns. We find that this process is markedly enhanced by the murine cytomegalovirus (MCMV)-encoded CC chemokine, MCK2, which promotes recruitment of CX3CR1 hi patrolling monocytes to initial infection sites in the mouse. There, these cells become infected and traffic via the bloodstream to distal sites. In contrast, inflammatory monocytes, the other major myelomonocytic subset, remain virus negative. CX3CR1 deficiency prevents patrolling monocyte migration on the vascular endothelium and interrupts MCMV dissemination to the salivary glands independent of antiviral NK and T cell immune control. In this manner, CX3CR1 hi patrolling monocytes serve as immune-privileged vehicles to transport MCMV via the bloodstream to distal organs. MCMV commandeers patrolling monocytes to mediate systemic infection and seed a persistent reservoir essential for horizontal transmission. |
| Databáze: | OpenAIRE |
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