The Effect of Age and Initial Central Retinal Thickness on Earlier Need of Repeat Ozurdex Treatment for Macular Edema Due to Retinal Vein Occlusion: A Retrospective Case Series
Autor: | Wen-Lu Chen, Chung-Yuan Kuo, Cheng-Wen Su, Chun-Ju Lin, Chun-Ting Lai, Jane-Ming Lin, Huan-Sheng Chen, Peng-Tai Tien, Yi-Yu Tsai |
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Rok vydání: | 2017 |
Předmět: |
Male
medicine.medical_specialty Retinal Vein Visual Acuity Dexamethasone Macular Edema Retina 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Central retinal vein occlusion Edema Retinal Vein Occlusion Occlusion medicine Dexamethasone Intravitreal Implant Humans Pharmacology (medical) 030212 general & internal medicine Glucocorticoids Macular edema Intraocular Pressure Retrospective Studies Drug Implants Pharmacology business.industry Age Factors Retinal Middle Aged medicine.disease Surgery Vitreous Body Ophthalmology chemistry Retreatment 030221 ophthalmology & optometry Branch retinal vein occlusion Female medicine.symptom business Tomography Optical Coherence |
Zdroj: | Journal of Ocular Pharmacology and Therapeutics. 33:763-772 |
ISSN: | 1557-7732 1080-7683 |
Popis: | To evaluate the effects of dexamethasone intravitreal implant (Ozurdex) and identify risk factors for repeated treatment in patients with macula edema due to branch retinal vein occlusion (BRVO) or central retinal vein occlusion (CRVO).Patients followed up for at least 6 months were enrolled from 2013 to 2016. Dexamethasone intravitreal implant was given as the baseline treatment. For evaluation of dexamethasone intravitreal implant effects and complications, the demographics, medical history, best-corrected visual acuity (BCVA), intraocular pressure, and central retinal thickness (CRT) were recorded. Multivariate Cox proportional hazard model and logistic regression were used to identify factors for repeated treatment.Twenty-three BRVO and 11 CRVO patients were enrolled. There were 15 males and 19 females. Fifteen (44.12%) patients needed only one dexamethasone intravitreal implant. The peak CRT and BCVA significantly improved. Comparing single-injection with multiple-injection group, age and initial CRT more than 400 μm were significantly higher in the multiple-injection group. From multivariate logistic regression and Cox proportional hazards analysis, patients with age older than 55 years and initial CRT more than 400 μm had higher risk for multiple injections.Patients receiving as-needed schedule of dexamethasone intravitreal implant had significant peak CRT and BCVA improvement. Age older than 55 years and initial CRT more than 400 μm were significant risk factors associated with repeated dexamethasone intravitreal implant treatment. |
Databáze: | OpenAIRE |
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