Comparative effectiveness of colony-stimulating factors in febrile neutropenia prophylaxis: how results are affected by research design
| Autor: | Qi Gong, Hairong Xu, Laura Becker, Robert G Deeter, Richard Barron, Henry J. Henk, Xiaoyan Li |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Research design
Comparative Effectiveness Research medicine.medical_specialty business.industry Health Policy Comparative effectiveness research Outcome assessment medicine.disease Checklist Administrative claims Colony-Stimulating Factors Research Design Neoplasms Cohort medicine Humans Disease process business Intensive care medicine Febrile neutropenia Febrile Neutropenia |
| Zdroj: | Journal of Comparative Effectiveness Research. 4:37-50 |
| ISSN: | 2042-6313 2042-6305 |
| Popis: | Aims: To examine the impact of research design on results in two published comparative effectiveness studies. Methods: Guidelines for comparative effectiveness research have recommended incorporating disease process in study design. Based on the recommendations, we develop a checklist of considerations and apply the checklist in review of two published studies on comparative effectiveness of colony-stimulating factors. Both studies used similar administrative claims data, but different methods, which resulted in directionally different estimates. Results: Major design differences between the two studies include: whether the timing of intervention in disease process was identified and whether study cohort and outcome assessment period were defined based on this temporal relationship. Conclusion: Disease process and timing of intervention should be incorporated into the design of comparative effectiveness studies. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|