Pregnancy at 40 years Old and Above: Obstetrical, Fetal, and Neonatal Outcomes. Is Age an Independent Risk Factor for Those Complications?
| Autor: | Hind Abbou, Paul Pirtea, Stephanie Rouanet, Ana Bouzaglou, Marie Carbonnel, Ines Aubenas, Jean-Marc Ayoubi |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Gestational hypertension
medicine.medical_specialty gestationnal diabetes complication advanced maternal age Preeclampsia neonatal preeclampsia 03 medical and health sciences 0302 clinical medicine Obstetrics and gynaecology medicine 030212 general & internal medicine Advanced maternal age Risk factor Original Research lcsh:R5-920 Pregnancy Fetus 030219 obstetrics & reproductive medicine Obstetrics business.industry General Medicine medicine.disease Gestational diabetes Medicine pregnancy lcsh:Medicine (General) business |
| Zdroj: | Frontiers in Medicine Frontiers in Medicine, Vol 7 (2020) |
| ISSN: | 2296-858X |
| Popis: | Objectives: Maternal age has been increasing for several decades with many of these late pregnancies between 40 and 45 years old. The main objective of this study is to assess whether maternal age is an independent factor of obstetric, fetal, and neonatal complications.Patients and methods: A monocentric, French study “exposed-unexposed” was conducted during 11 years in a maternity level IIB. Maternal and perinatal outcomes were studied using univariates and multivariate analysis. We compared women aged 40 and above in a 1:1 ratio with women of 25–35 years old.Results: One thousand nine hundred eighty-two women were 40 or older (mean age: 41.9) on the day of their delivery and compared to other 1,982 women who were aged between 25 and 35 years old (mean age: 30.7) Preeclampsia, gestational diabetes, were significantly higher in the study group (4.6 vs. 1.5% and 14.5 vs. 6.9%, respectively, p < 0.001). We found also a significant difference for gestational hypertension (3.1 vs. 1.1% p < 0.001), preterm birth (10.4 vs. 6.5% p < 0.001), cesarean (16.6 vs. 5.4% for scheduled cesarean, and 50.4 vs. 13.9% for emergency cesarean, p < 0.001) and fetal death in utero (2.1 vs. 0.5% in the study group, p < 0.001). These results were also significantly different in multivariate analysis.Conclusion: A pregnancy after 40 years old is worth considering today as far as the risk factors are controlled and understand by the patient and the obstetrician. However, they have a significantly higher risks of cesarean, preterm delivery, pre-eclampsia, gestational diabetes, and fetal death in utero (FDIU). It is therefore the responsibility of the obstetrician to inform correctly these women in a detailed way, to reassure them and to adapt the monitoring of their pregnancy accordingly. |
| Databáze: | OpenAIRE |
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