BPC 157: The counteraction of succinylcholine, hyperkalemia, and arrhythmias
| Autor: | Sandra Uzun, Vasilije Stambolija, Domagoj Drmic, Jelena Radonic, Danijela Kolenc, Zeljko Romic, Bozidar Duplancic, Gordana Zivanovic-Posilovic, Sven Seiwerth, Tamara Perleta Stambolija, Jadranka Katancic Holjevac, Viktor Duzel, Tamara Murselovic, Predrag Sikiric |
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| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Male
Hyperkalemia Muscle Fibers Skeletal Succinylcholine 01 natural sciences 03 medical and health sciences 0302 clinical medicine Edema Paralysis medicine Animals Rats Wistar Psychomotor Agitation Muscle contracture Pharmacology Dose-Response Relationship Drug business.industry Skeletal muscle Proteins Arrhythmias Cardiac Immobility Response Tonic Peptide Fragments 0104 chemical sciences Diaphragm (structural system) Rats 010404 medicinal & biomolecular chemistry medicine.anatomical_structure Anesthesia Hyperalgesia Arrhythmias BPC 157 medicine.symptom business 030217 neurology & neurosurgery Muscle contraction Muscle Contraction |
| Popis: | After the demonstration of its life-saving effect in severe hyperkalemia and the recovery of skeletal muscle after injury, pentadecapeptide BPC 157 has been shown to attenuate the local paralytic effect induced by succinylcholine, in addition to systemic muscle disability (and consequent muscle damage). Hyperkalemia, arrhythmias and a rise in serum enzyme values, were counteracted in rats. Assessments were made at 3 and 30min and 1, 3, 5, and 7 days after succinylcholine administration (1.0mg/kg into the right anterior tibial muscle). BPC 157 (10µg/kg, 10ng/kg) (given intraperitoneally 30min before or immediately after succinylcholine or per-orally in drinking water through 24h until succinylcholine administration) mitigated both local and systemic disturbances. BPC 157 completely eliminated hyperkalemia and arrhythmias, markedly attenuated or erradicated behavioral agitation, muscle twitches, motionless resting and completely eliminated post-succinylcholine hyperalgesia. BPC 157 immediately eliminated leg contractures and counteracted both edema and the decrease in muscle fibers in the diaphragm and injected/non-injected anterior tibial muscles. Therefore, the depolarizing neuromuscular blocker effects of succinylcholine were successfully antagonized. |
| Databáze: | OpenAIRE |
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