Diabetes duration and glycaemic control as predictors of cardiovascular disease and mortality
| Autor: | Hai-Lian Yang, Fu-Rong Li, Guo-Chong Chen, Rui Zhou, Xian-Bo Wu, Jiazhen Zheng, Meng-Chen Zou, Xiao-Xiang Wu |
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| Rok vydání: | 2021 |
| Předmět: |
Diabetes duration
medicine.medical_specialty Endocrinology Diabetes and Metabolism 030209 endocrinology & metabolism Glycemic Control Disease 030204 cardiovascular system & hematology 03 medical and health sciences 0302 clinical medicine Endocrinology Risk Factors Internal medicine Diabetes mellitus Internal Medicine Humans Medicine Glycated Hemoglobin business.industry Proportional hazards model Hazard ratio Anthropometry medicine.disease Confidence interval Diabetes Mellitus Type 2 Cardiovascular Diseases business Cohort study |
| Zdroj: | Diabetes, Obesity and Metabolism. 23:1361-1370 |
| ISSN: | 1463-1326 1462-8902 |
| Popis: | AIMS To assess the associations of diabetes duration and glycaemic control (defined by plasma glycated haemoglobin [HbA1c] level) with the risks of cardiovascular disease (CVD) and all-cause mortality and to determine whether the addition of either or both to the established CVD risk factors can improve predictions. MATERIALS AND METHODS A total of 435 679 participants from the UK Biobank without CVD at baseline were included. Cox models adjusting for classic risk factors (sociodemographic and anthropometric characteristics, lipid profiles and medication use) were used, and predictive utility was determined by the C-index and net reclassification improvement (NRI). RESULTS Compared with participants without diabetes, participants with longer diabetes durations and poorer glycaemic control had a higher risk of fatal/nonfatal CVD. Among participants with diabetes, the fully-adjusted hazard ratios (HRs) for diabetes durations of 5 to |
| Databáze: | OpenAIRE |
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