Expression and Localisation of CD44 Antigen as a Prognostic Factor of Oral Leukoplakia
| Autor: | Šimons Svirskis, Regīna Kleina, Ingrīda Čēma, Anita Dabuzinskiene, Madara Dzudzilo |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Prognostic factor cell-surface glycoprotein Science Peripheral blood mononuclear cell Malignant transformation 03 medical and health sciences 0302 clinical medicine Antigen medicine mononuclear cells of lamina propria oral precancers Oral mucosa Lamina propria Multidisciplinary biology business.industry CD44 Oral leukoplakia 030104 developmental biology medicine.anatomical_structure 030220 oncology & carcinogenesis Cancer research biology.protein business |
| Zdroj: | Proceedings of the Latvian Academy of Sciences. Section B, Natural Sciences, Vol 75, Iss 2, Pp 68-74 (2021) |
| Popis: | It is essential to identify markers that could indicate the presence of early molecular changes in premalignant tissues like oral leukoplakia (OL). CD44 adhesion molecule is not only a stem cell marker, but also determines cell proliferation and migration in malignant processes. The aim of our study was to assess the amount and pattern of CD44 antigen expression by epithelial and mononuclear cells in the lamina propria under OL and their role in premalignant lesions. The current study included 102 cases of OL and ten biopsies from healthy oral mucosa. Immunohistochemical CD44 antigen expression was determined in 34 cases by a standard EnVision imaging system in three points of OL: both edges and centre. Statistical analysis was done using GraphPad Prism software version 8.4.0. In OL, statistically significant overexpression of membranous CD44 was demonstrated compared to healthy mucosa (p < 0.0001). The intra-cytoplasmatic CD44 expression of epithelium together with characteristic nuclear changes may be used as a predictive factor for potential malignant transformation of non-homogenous leukoplakia. CD44 expression in mononuclear cells under the basal membrane in OL (p < 0.05) possibly influences the process of premalignant lesion transformation into intraepithelial cancer. Further study of CD44 antigen expression in intra-cytoplasmatic structures is required for better explanation of the role of this glycoprotein. |
| Databáze: | OpenAIRE |
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