Innate NKT lymphocytes confer superior adaptive immunity via tumor-capturing dendritic cells
| Autor: | Juliana Idoyaga, Anthony J. Bonito, Ralph M. Steinman, Shin-ichiro Fujii, Yang Liu, Xue-Feng Bai, Rosa Wainstok, José Mordoh, Kang Liu, Anna Charalambous |
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| Rok vydání: | 2005 |
| Předmět: |
CD4-Positive T-Lymphocytes
Lymphoma major histocompatibility antigen class 1 cell maturation animal cell CD8-Positive T-Lymphocytes Lymphocyte Activation Mice 0302 clinical medicine antibody drug uptake purl.org/becyt/ford/3.2 [https] T lymphocyte drug delivery system Immunology and Allergy Antigen Presentation Mice Inbred BALB C 0303 health sciences irradiation article Cell Differentiation CD8 antigen lymph node Natural killer T cell Acquired immune system major histocompatibility complex alpha CD40 antibody polyinosinic polycytidylic acid unclassified drug 3. Good health alpha galactosylceramide lymphoid organ Killer Cells Natural female medicine.anatomical_structure priority journal Female purl.org/becyt/ford/3 [https] CD4 antigen dendritic cell animal experiment Immunology Antigen presentation Biology Cancer Vaccines Article Natural killer cell 03 medical and health sciences Immune system adjuvant plasmacytoma Adjuvants Immunologic Antigen Antigens Neoplasm medicine Animals controlled study mouse Tumors 030304 developmental biology nonhuman animal model Immunity Immunotherapy Active Neoplasms Experimental Dendritic Cells Dendritic cell natural killer cell vaccination tumor resistance tumor immunity Gamma Rays spleen Lymph Nodes glycolipid Spleen tumor antigen Neoplasm Transplantation CD8 Plasmacytoma spleen cell 030215 immunology |
| Zdroj: | CONICET Digital (CONICET) Consejo Nacional de Investigaciones Científicas y Técnicas instacron:CONICET J. Exp. Med. 2005;202(11):1507-1516 Biblioteca Digital (UBA-FCEN) Universidad Nacional de Buenos Aires. Facultad de Ciencias Exactas y Naturales instacron:UBA-FCEN The Journal of Experimental Medicine |
| ISSN: | 1540-9538 0022-1007 |
| DOI: | 10.1084/jem.20050956 |
| Popis: | If irradiated tumor cells could be rendered immunogenic, they would provide a safe, broad, and patient-specific array of antigens for immunotherapies. Prior approaches have emphasized genetic transduction of live tumor cells to express cytokines, costimulators, and surrogate foreign antigens. We asked if immunity could be achieved by delivering irradiated, major histocompatibility complex-negative plasmacytoma cells to maturing mouse dendritic cells (DCs) within lymphoid organs. Tumor cells injected intravenously (i.v.) were captured by splenic DCs, whereas subcutaneous (s.c.) injection led only to weak uptake in lymph node or spleen. The natural killer T (NKT) cells mobilizing glycolipid α-galactosyl ceramide, used to mature splenic DCs, served as an effective adjuvant to induce protective immunity. This adjuvant function was mimicked by a combination of poly IC and agonistic αCD40 antibody. The adjuvant glycolipid had to be coadministered with tumor cells i.v. rather than s.c. Specific resistance was generated both to a plasmacytoma and lymphoma. The resistance afforded by a single vaccination lasted >2 mo and required both CD4+ and CD8+ T cells. Mature tumor capturing DCs stimulated the differentiation of P1A tumor antigen-specific, CD8+ T cells and uniquely transferred tumor resistance to naive mice. Therefore, the access of dying tumor cells to DCs that are maturing to activated NKT cells efficiently induces long-lived adaptive resistance. Fil: Liu, Kang. The Rockefeller University; Estados Unidos Fil: Idoyaga, Juliana. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina Fil: Charalambous, Anna. The Rockefeller University; Estados Unidos Fil: Fujii, Shin Ichiro. The Rockefeller University; Estados Unidos Fil: Bonito, Anthony. The Rockefeller University; Estados Unidos Fil: Mordoh, Jose. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina Fil: Wainstok, Rosa. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales; Argentina Fil: Bai, Xue Feng. Ohio State University; Estados Unidos Fil: Liu, Yang. Ohio State University; Estados Unidos Fil: Steinman, Ralph M.. The Rockefeller University; Estados Unidos |
| Databáze: | OpenAIRE |
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