Depression is associated with increased occurrence of left ventricle concentric geometry in older subjects independently of blood pressure levels

Autor: Angelo Scuteri, Anna Modestino, Roberta Coluccia, Lorenzo Del Castello, Edoardo Nevola, Massimo Volpe
Rok vydání: 2010
Předmět:
Male
medicine.medical_specialty
Endocrinology
Diabetes and Metabolism
Heart Ventricles
Medicine (miscellaneous)
Blood Pressure
Comorbidity
Left ventricular hypertrophy
Cohort Studies
Diabetes Complications
Vascular Stiffness
Risk Factors
Internal medicine
Diabetes mellitus
medicine
Prevalence
Eccentric
Humans
cardiovascular diseases
Risk factor
Geriatric Assessment
Depression (differential diagnoses)
Aged
Ultrasonography
left ventricular remodeling
Aged
80 and over
Psychiatric Status Rating Scales
Nutrition and Dietetics
Ventricular Remodeling
business.industry
Depression
depression
elderly subjects
hypertension
left ventricular hypertrophy
risk factors
medicine.disease
medicine.anatomical_structure
Blood pressure
Cross-Sectional Studies
Italy
Ventricle
Hypertension
Cardiology
Geriatric Depression Scale
Female
Hypertrophy
Left Ventricular
Cardiology and Cardiovascular Medicine
business
Zdroj: Nutrition, metabolism, and cardiovascular diseases : NMCD. 21(12)
ISSN: 1590-3729
Popis: Background and Aim Depression is emerging as an independent risk factor for CV events, though mechanisms underlying this association are unknown. We investigated the relation between depression and LV hypertrophy (LVH) and LV structure in a group of elderly subjects. Methods and Results Three hundred seventy patients (mean age 79 ± 6 years) were enrolled. CV risk factors were assessed. Depression was defined as a score ≥6 on the 15-item Geriatric Depression Scale. On the basis of the presence of LVH and of LV relative wall thickness (RWT) 4 echocardiographic patterns of LV adaptation were defined: concentric LVH (LVH with increased RWT); eccentric LVH (LVH with normal RWT); concentric LV remodeling (no LVH with increased RWT); normal LV (no LVH with normal RWT). Prevalence of hypertension was approximately 86% and 24.7% had diabetes (n.s. depressed vs not depressed subjects). BP was comparable in these two groups (134.7 ± 1.4 vs 135.3 ± 1.8 mmHg, 77.1 ± 0.8 vs 76.3 ± 1.0 mmHg for SBP and DBP respectively). Depressed subjects (n = 165) showed a significantly higher occurrence of concentric LVH than not depressed, after adjustment for age, sex, and hypertension. Depression was associated with a 2.1 fold higher risk of showing a LV concentric, either remodeling or LVH, pattern after adjustment for age, sex, and traditional CV risk factors. Conclusions Depression is accompanied by a higher occurrence of concentric LVH in elderly subjects, independently of BP levels.
Databáze: OpenAIRE
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