An increase in vitamin a status by the feeding of conjugated linoleic acid
| Autor: | Gianfranca Carta, Maria Paola Melis, Viviana Casu, Clement Ip, Elisabetta Angioni, Stefania Scrugli, Francesco P. Corongiu, Sebastiano Banni |
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| Rok vydání: | 1999 |
| Předmět: |
Vitamin
Cancer Research medicine.medical_specialty Linoleic acid Conjugated linoleic acid Mammary gland Medicine (miscellaneous) Mammary Neoplasms Animal Biology Linoleic Acid Rats Sprague-Dawley chemistry.chemical_compound Mammary Glands Animal Internal medicine medicine Animals Vitamin A Anticarcinogen Chromatography High Pressure Liquid Nutrition and Dietetics integumentary system Retinol food and beverages Metabolism Diet Rats Specific Pathogen-Free Organisms Endocrinology medicine.anatomical_structure Liver Oncology chemistry Mammary carcinogenesis Female lipids (amino acids peptides and proteins) |
| Zdroj: | Nutrition and Cancer. 33:53-57 |
| ISSN: | 1532-7914 0163-5581 |
| DOI: | 10.1080/01635589909514748 |
| Popis: | Previous research indicated that conjugated linoleic acid (CLA) is a potent inhibitor of mammary carcinogenesis. The present study showed a progressive increase in retinol (vitamin A alcohol) in the liver in proportion to CLA intake in rats that were fed different levels of CLA (in increments of 0.5%) for 1 month. The escalation reached a magnitude of about fivefold over the control at 2% dietary CLA. In contrast, the increase in liver retinyl esters peaked at about twofold between 0.5% and 1% CLA. Only retinol was detected in mammary tissue; a maximal twofold increase was attained at 0.5% CLA, and no dose-response effect was evident. The above findings are discussed in relation to two important questions: 1) How does CLA raise vitamin A status in the animal? 2) Is the increase in vitamin A associated with the anticarcinogenic effect of CLA? |
| Databáze: | OpenAIRE |
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