Ameliorative Effect of the Oral Administration of Chuquiraga spinosa in a Murine Model of Breast Cancer Induced with 7,12-Dimethylbenz[a]anthracene (DMBA)
| Autor: | Ricardo Ángel Yuli-Posadas, Johnny Aldo Tinco-Jayo, Juan Pedro Rojas-Armas, Victor Fernández-Guzmán, Renán Hañari-Quispe, Oscar Herrera-Calderon, Jorge Luis Arroyo-Acevedo, Abdur Rauf, Linder Figueroa-Salvador |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Antioxidant
medicine.medical_treatment DMBA Breast tumor Pharmacology Phytochemical chemistry.chemical_compound Breast cancer Oral administration Drug Discovery Alkaline phosphatase medicine Alanine aminotransferasea skin and connective tissue diseases Preventive medicine Toxicity business.industry 7 12-Dimethylbenz[a]anthracene Neoplasias de la Mama Cancer Cáncer Alkaloid derivative medicine.disease 7 12 dimethylbenz[a]anthracene chemistry Anticarcinogenic agent business |
| Zdroj: | Universidad Peruana de Ciencias Aplicadas (UPC) Repositorio Academico-UPC UPC-Institucional Universidad Peruana de Ciencias Aplicadas instacron:UPC Pharmacognosy Journal Universidad Continental Repositorio Institucional-Continental CONTINENTAL-Institucional instacron:CONTINENTAL |
| Popis: | Objective: To determine the ameliorative effect of the ethanolic extract of Chuquiraga spinosa (ChS) on 7,12-Dimethylbenz[a]anthracene (DMBA)-induced breast cancer in rats. Methods: 36 female Holztman rats were divided into 6 groups. I) The negative control group received physiological saline (PS). II) ChS-200 group received 200 mg/kg of ChS. III) DMBA group was induced with DMBA (20 mg/Kg) dissolved in PS and administrated orally for 15 weeks. IV) DMBA + ChS-50 group, V) DMBA + ChS-250 group, and VI) DMBA + ChS-500 group, which received the extract orally for 15 weeks after DMBA induction. All data were expressed as mean and standard deviation. One-way analysis of variance (ANOVA) followed by Dunnet test was carried out to compare the mean value of different groups Histopathological analysis was evaluated by using Image J software. Results: Hematology showed that the triglyceride level was significantly lowered (P< 0.01) and high-density lipoprotein (HDL) level was significantly increased (P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|