Mitophagy, a potential therapeutic target for stroke
| Autor: | Qiuxin Chen, Hao Liu, Wei Teng, Xueping Yu, Xiaohong Dai, Ruiqiao Guan, Wei Zou |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Programmed cell death Mitochondria autophagy Endocrinology Diabetes and Metabolism Clinical Biochemistry lcsh:Medicine Review Mitochondrion 03 medical and health sciences chemistry.chemical_compound Mice 0302 clinical medicine Mitophagy Autophagy Animals Humans Pharmacology (medical) Molecular Biology chemistry.chemical_classification Reactive oxygen species Biochemistry (medical) lcsh:R Cell Biology General Medicine Cell biology Rats Mitochondria Stroke 030104 developmental biology Mitochondrial permeability transition pore chemistry Signal transduction Adenosine triphosphate 030217 neurology & neurosurgery Signal Transduction |
| Zdroj: | Journal of Biomedical Science, Vol 25, Iss 1, Pp 1-16 (2018) Journal of Biomedical Science |
| ISSN: | 1423-0127 |
| DOI: | 10.1186/s12929-018-0487-4 |
| Popis: | Mitochondria autophagy, termed as mitophagy, is a mechanism of specific autophagic elimination of mitochondria. Mitophagy controls the quality and the number of mitochondria, eliminating dysfunctional or excessive mitochondria that can generate reactive oxygen species (ROS) and cause cell death. Mitochondria are centrally implicated in neuron and tissue injury after stroke, due to the function of supplying adenosine triphosphate (ATP) to the tissue, regulating oxidative metabolism during the pathologic process, and contribution to apoptotic cell death after stroke. As a catabolic mechanism, mitophagy links numbers of a complex network of mitochondria, and affects mitochondrial dynamic process, fusion and fission, reducing mitochondrial production of ROS, mediated by the mitochondrial permeability transition pore (MPTP). The precise nature of mitophagy’s involvement in stroke, and its underlying molecular mechanisms, have yet to be fully clarified. This review aims to provide a comprehensive overview of the integration of mitochondria with mitophagy, also to introduce and discuss recent advances in the understanding of the potential role, and possible signaling pathway, of mitophagy in the pathological processes of both hemorrhagic and ischemic stroke. The author also provides evidence to explain the dual role of mitophagy in stroke. |
| Databáze: | OpenAIRE |
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