Electro-physiological changes in the brain induced by caffeine or glucose nasal spray
| Autor: | Tine Torbeyns, Uros Marusic, Bart Roelands, K De Pauw, Romain Meeusen, J Van Cutsem |
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| Přispěvatelé: | Human Physiology and Sports Physiotherapy Research Group, Physiotherapy, Human Physiology and Anatomy, Human Physiology and Special Physiology of Physical Education, Faculty of Physical Education and Physical Therapy |
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Male
medicine.medical_specialty sLORETA medicine.medical_treatment Electroencephalography/methods Reaction Time/drug effects Sensory system Electroencephalography Placebo Brain mapping Caffeine/pharmacology 03 medical and health sciences 0302 clinical medicine Double-Blind Method Caffeine Internal medicine Reaction Time medicine Humans EEG Anterior cingulate cortex Administration Intranasal Brain Mapping Brain/drug effects medicine.diagnostic_test ERP P300 Brain 030229 sport sciences Nasal Sprays Glucose/pharmacology attention Glucose medicine.anatomical_structure Endocrinology Nasal spray Anesthesia Stroop Test young adult Stroop pharmacology Psychology Insula 030217 neurology & neurosurgery Source localization Stroop effect |
| DOI: | 10.1007/s00213-016-4435-2 |
| Popis: | OBJECTIVE: A direct link between the mouth cavity and the brain for glucose (GLUC) and caffeine (CAF) has been established. The aim of this study is to determine whether a direct link for both substrates also exist between the nasal cavity and the brain. METHODS: Ten healthy male subjects (age 22 ± 1 years) performed three experimental trials, separated by at least 2 days. Each trial included a 20-s nasal spray (NAS) period in which solutions placebo (PLAC), GLUC, or CAF were provided in a double-blind, randomized order. During each trial, four cognitive Stroop tasks were performed: two familiarization trials and one pre- and one post-NAS trial. Reaction times and accuracy for different stimuli (neutral, NEUTR; congruent, CON; incongruent INCON) were determined. Electroencephalography was continuously measured throughout the trials. During the Stroop tasks pre- and post-NAS, the P300 was assessed and during NAS, source localization was performed using standardized low-resolution brain electromagnetic tomography (sLORETA). RESULTS AND DISCUSSION: NAS activated the anterior cingulate cortex (ACC). CAF-NAS also increased θ and β activity in frontal cortices. Furthermore, GLUC-NAS increased the β activity within the insula. GLUC-NAS also increased the P300 amplitude with INCON (P = 0.046) and reduced P300 amplitude at F3-F4 and P300 latency at CP1-CP2-Cz with NEUTR (P = 0.001 and P = 0.016, respectively). The existence of nasal bitter and sweet taste receptors possibly induce these brain responses. CONCLUSION: Greater cognitive efficiency was observed with GLUC-NAS. CAF-NAS activated cingulate, insular, and sensorymotor cortices, whereas GLUC-NAS activated sensory, cingulate, and insular cortices. However, no effect on the Stroop task was found. |
| Databáze: | OpenAIRE |
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