Effects of Exogenous Melatonin Administration and Withdrawal in Five Patients With Rapid-Cycling Bipolar Disorder
| Autor: | Thomas A. Wehr, Susana Feldman-Naim, Norman E. Rosenthal, Ellen Leibenluft, Erick H. Turner |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
Sleep Wake Disorders
endocrine system medicine.medical_specialty Bipolar Disorder medicine.medical_treatment Drug Administration Schedule Placebos Melatonin Pharmacotherapy Double-Blind Method Internal medicine medicine Humans Bipolar disorder Chemotherapy Middle Aged medicine.disease Circadian Rhythm Substance Withdrawal Syndrome Affect Psychiatry and Mental health Regimen Endocrinology Mood Mood disorders Drug Therapy Combination Female Sleep onset Sleep Psychology hormones hormone substitutes and hormone antagonists medicine.drug |
| Zdroj: | The Journal of Clinical Psychiatry. 58:383-388 |
| ISSN: | 0160-6689 |
| Popis: | Background: The ready availability of exogenous melatonin means that its use in patients with mood disorders is probably not uncommon. Nonetheless, few controlled trials of exogenous melatonin in these patients have been conducted. Method: Five patients with rapid-cycling DSM-III-R bipolar disorder were treated with melatonin 10 mg q.d. at 10:00 p.m. for 12 weeks. Melatonin was added to a stable regimen of medication and administered in a double-blind, placebo-controlled fashion. Results: Melantonin administration had no positive effects. One patient developed a freerunning (unentrained) sleep-wake cycle after melatonin withdrawal. In addition, in both this and a second patient, there is evidence that the administration of exogenous melatonin may have suppressed the secretion of endogenous melatonin. Conclusion: The administration of melatonin had no significant effects on mood or sleep. However, melatonin withdrawal delayed sleep onset time and may have had some mild moodelevating effects. |
| Databáze: | OpenAIRE |
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