The functional characterization of callosal connections
| Autor: | Maurice Ptito, Franco Lepore, Francisco Aboitiz, Chantal Milleret, Roberto Caminiti, Alexandra Battaglia-Mayer, Kerstin E. Schmidt, Maria G. Knyazeva, Matteo Caleo, Muhamed Barakovic, Mara Fabri, Giorgio M. Innocenti, Carlo Alberto Marzi |
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| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: |
callosal conduction velocity
callosal disconnection syndromes Computer science VM vertical meridian of the visual field receptive-field properties Callosal axon diameter Callosal conduction velocity Callosal connections flexibility Callosal disconnection syndromes Callosal interhemispheric transfer Corpus callosum Review Article primary auditory-cortex corpus callosum AAF anterior auditory field EP evoked potential Operation mode EPSP excitatory post-synaptic potential Neural Pathways posterior corpus-callosum Direct stimulation Neurons CPN callosal projection neuron callosal connections flexibility Synaptic interaction GI primary gustatory area General Neuroscience SC split-chiasm Brain A1 primary auditory cortex ICoh interhemispheric EEG coherence BOLD blood oxygen level dependent General theory Cortical network DW-MRI diffusion-weighted magnetic resonance imaging tractography Excitatory postsynaptic potential parietal lobule projections callosal axon diameter callosal interhemispheric transfer body midline representation RF receptive field CC corpus callosum Inhibitory postsynaptic potential EEG electroencephalogram V1 (primary visual cortex area 17) LFPs local field potentials Animals Humans interhemispheric eeg coherence SI primary somatosensory cortex primary visual-cortex EM electron microscopy M1 primary motor cortex TMS transcranial magnetic stimulation BDA biotinylated dextran amine axon diameter distribution Axons DCM dynamic causal modeling SCC split corpus callosum V2 (secondary visual cortex area 18) nervous system SII secondary somatosensory cortex 2nd somatosensory cortex Neuroscience stimulus-dependent changes |
| Zdroj: | Innocenti, G M, Schmidt, K, Milleret, C, Fabri, M, Knyazeva, M G, Battaglia-Mayer, A, Aboitiz, F, Ptito, M, Caleo, M, Marzi, C A, Barakovic, M, Lepore, F & Caminiti, R 2022, ' The functional characterization of callosal connections ', Progress in Neurobiology, vol. 208, 102186 . https://doi.org/10.1016/j.pneurobio.2021.102186 Repositório Institucional da UFRN Universidade Federal do Rio Grande do Norte (UFRN) instacron:UFRN Progress in Neurobiology |
| DOI: | 10.1016/j.pneurobio.2021.102186 |
| Popis: | Highlights • The functional characterization of callosal connections is informed by anatomical data. • Callosal connections play a conditional driving role depending on the brain state and behavioral demands. • Callosal connections play a modulatory function, in addition to a driving role. • The corpus callosum participates in learning and interhemispheric transfer of sensorimotor habits. • The corpus callosum contributes to language processing and cognitive functions. The brain operates through the synaptic interaction of distant neurons within flexible, often heterogeneous, distributed systems. Histological studies have detailed the connections between distant neurons, but their functional characterization deserves further exploration. Studies performed on the corpus callosum in animals and humans are unique in that they capitalize on results obtained from several neuroscience disciplines. Such data inspire a new interpretation of the function of callosal connections and delineate a novel road map, thus paving the way toward a general theory of cortico-cortical connectivity. Here we suggest that callosal axons can drive their post-synaptic targets preferentially when coupled to other inputs endowing the cortical network with a high degree of conditionality. This might depend on several factors, such as their pattern of convergence-divergence, the excitatory and inhibitory operation mode, the range of conduction velocities, the variety of homotopic and heterotopic projections and, finally, the state-dependency of their firing. We propose that, in addition to direct stimulation of post-synaptic targets, callosal axons often play a conditional driving or modulatory role, which depends on task contingencies, as documented by several recent studies. |
| Databáze: | OpenAIRE |
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