Safety and efficacy of fiducial marker implantation for robotic stereotactic body radiation therapy with fiducial tracking

Autor: Jean-Michel Vannetzel, Denis Foster, Marc Bollet, A. Toledano, Imane Khemiri, Rie von Eyben, I. Darmon, Gauthier Bouilhol, Noura Sellami, Aurelie Vouillaume, Luc Rotenberg, Remi Tannouri, Hanah Lamallem, Nathaniel Scher, Olivier Bauduceau
Rok vydání: 2019
Předmět:
lcsh:Medical physics. Medical radiology. Nuclear medicine
Adult
Male
medicine.medical_specialty
Stereotactic body radiation therapy
lcsh:R895-920
medicine.medical_treatment
Technical success
Stereotactic radiation therapy
Radiosurgery
lcsh:RC254-282
030218 nuclear medicine & medical imaging
03 medical and health sciences
0302 clinical medicine
Fiducial Markers
Neoplasms
medicine
Humans
Radiology
Nuclear Medicine and imaging
Implantation procedure
Fiducial marker
Image-guided radiation therapy
Aged
Retrospective Studies
Aged
80 and over
Image guided radiation therapy
business.industry
Research
Common Terminology Criteria for Adverse Events
Middle Aged
lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Prognosis
Radiation therapy
Oncology
030220 oncology & carcinogenesis
Feasibility Studies
Female
Radiology
business
Zdroj: Radiation Oncology (London, England)
Radiation Oncology, Vol 14, Iss 1, Pp 1-8 (2019)
ISSN: 1748-717X
Popis: Purpose The purpose of this study was to assess the feasibility, efficacy and toxicity of fiducial marker implantation and tracking in CyberKnife® stereotactic radiation therapy (SBRT) applied to extracranial locations. Materials and method This is a retrospective, single-centre, observational study to collect the data of all patients treated by stereotactic radiation therapy with fiducial marker tracking at extracranial locations, conducted between June 2014 and November 2017. Information regarding the implantation procedure, the types of toxicity related to marker implantation and the number of markers implanted/tracked during treatment were collected. Complication rates were evaluated using the CTCAE v4 [Common Terminology Criteria for Adverse Events] scale. The technical success rate was based on the ability to optimally track the tumor throughout all treatment fractions. Results Out of 2505 patients treated by stereotactic radiation therapy, 25% received treatment with fiducial marker tracking. The total number of implantation procedures was 616 and 1543 fiducial markers were implanted. The implantation-related complication rate was 3%, with 16 Grade 1 events and 4 Grade 2 events. The number of treated patients and the number of implanted markers has gradually increased since the technique was first implemented. The median treatment time was 27 min (range 10–76). 1295 fiducials were effectively tracked throughout all treatment fractions, corresponding to a technical success rate of 84%. The difference between the number of fiducials implanted and those tracked during treatment decreased significantly as the site’s experience increased. Conclusion Fiducial marker implantation and tracking is feasible, well-tolerated, and technically effective technique in SBRT for extracranial tumors.
Databáze: OpenAIRE
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