Aberrant DNA Methylation Mediates the Transgenerational Risk of Metabolic and Chronic Disease Due to Maternal Obesity and Overnutrition
Autor: | Yan Li, Carol A. Pollock, Sonia Saad |
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Jazyk: | angličtina |
Rok vydání: | 2021 |
Předmět: |
Male
Offspring Review Disease QH426-470 Bioinformatics metabolic diseases Fetal Development Obesity Maternal Overnutrition overnutrition Pregnancy Risk Factors Diabetes mellitus medicine Genetics Animals Humans Epigenetics Genetics (clinical) DNA methylation offspring business.industry Fatty liver Infant Newborn medicine.disease Obesity Pregnancy Complications maternal obesity Prenatal Exposure Delayed Effects Chronic Disease Female Disease Susceptibility business |
Zdroj: | Genes, Vol 12, Iss 1653, p 1653 (2021) Genes |
ISSN: | 2073-4425 |
Popis: | Maternal obesity is a rapidly evolving universal epidemic leading to acute and long-term medical and obstetric health issues, including increased maternal risks of gestational diabetes, hypertension and pre-eclampsia, and the future risks for offspring’s predisposition to metabolic diseases. Epigenetic modification, in particular DNA methylation, represents a mechanism whereby environmental effects impact on the phenotypic expression of human disease. Maternal obesity or overnutrition contributes to the alterations in DNA methylation during early life which, through fetal programming, can predispose the offspring to many metabolic and chronic diseases, such as non-alcoholic fatty liver disease, obesity, diabetes, and chronic kidney disease. This review aims to summarize findings from human and animal studies, which support the role of maternal obesity in fetal programing and the potential benefit of altering DNA methylation to limit maternal obesity related disease in the offspring. |
Databáze: | OpenAIRE |
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