The role of Gα protein signaling in the membrane estrogen receptor-mediated signaling
| Autor: | Chao Fan, Yaxing Zhang, Lin Wu, Shuhui Zheng, Tommaso Simoncini, Xiaodong Fu, Jingxia Lin |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Membrane estrogen receptor
medicine.drug_class G protein Gα protein Endocrinology Diabetes and Metabolism Estrogen receptor Biology Energy homeostasis Cell membrane Endocrinology RNA interference medicine Animals Humans extranuclear action membrane estrogen receptors Cell Membrane Obstetrics and Gynecology Estrogen GTP-Binding Protein alpha Subunits Cell biology medicine.anatomical_structure Receptors Estrogen Signal transduction Signal Transduction |
| Zdroj: | Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology. 37(1) |
| ISSN: | 1473-0766 |
| Popis: | Estrogens exert rapid, extranuclear effects by their action on the plasma membrane estrogen receptors (mERs). Gα protein associated with the cell membrane is involved in many important processes regulated by estrogens. However, the Gα's role in the mER-mediated signaling and the signaling pathways involved are poorly understood. This review aims to outline the Gα's role in the mER-mediated signaling. Immunoblotting, immunofluorescence, co-immunoprecipitation, and RNA interference were carried out using vascular endothelial cells (ECs) and human breast carcinoma cell lines as experimental models. Electrophysiology and immunocytochemistry were carried out using guinea pigs as animal models. Recent advances suggest that the signaling of mERα through Gα is required for vascular EC migration or endothelial H2S release, while Gα13 is involved in estrogen-induced breast cancer cell invasion. Besides, the Gαq-coupled PLC-PKC-PKA pathway is critical for the neural regulation of energy homeostasis. This review summarizes the contributions of Gα to mER-mediated signaling, including cardiovascular protection, breast cancer metastasis, neural regulation of homeostatic functions, and osteogenesis. |
| Databáze: | OpenAIRE |
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