Abnormalities of ascorbic acid metabolism and diabetic control: differences between diabetic patients and diabetic rats
| Autor: | Margaret McGill, Scott Heffernan, Elizabeth J. Fisher, C. Capogreco, John R. Turtle, S. McLennan, Dennis K. Yue |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
Adult
Vitamin medicine.medical_specialty Endocrinology Diabetes and Metabolism Urinary system Ascorbic Acid Urine Diabetes Mellitus Experimental Excretion chemistry.chemical_compound Endocrinology Internal medicine Diabetes mellitus Blood plasma Diabetes Mellitus Internal Medicine medicine Animals Humans business.industry Rats Inbred Strains General Medicine Middle Aged Ascorbic acid medicine.disease Rats Disease Models Animal chemistry Female Hemoglobin business |
| Zdroj: | Diabetes Research and Clinical Practice. 9:239-244 |
| ISSN: | 0168-8227 |
| DOI: | 10.1016/0168-8227(90)90051-t |
| Popis: | Ascorbic acid is required in the synthesis of collagen and is also an important anti-oxidant. In a previous study, plasma ascorbic acid concentration was found to be decreased in diabetic patients but there was no relationship with blood glucose level. In the current study of diabetic patients, both plasma ascorbic acid and its urinary excretion correlated inversely with glycosylated hemoglobin level. Plasma ascorbic acid was also lower in diabetic rats but urinary ascorbic acid was elevated. The divergent trend in urinary ascorbic acid excretion observed in diabetic patients and diabetic rats may be due to difference in the ability of these two species to synthesize ascorbic acid. Difference in renal reabsorption of ascorbic acid may also be a relevant factor. The lower plasma and urinary ascorbic acid levels in diabetic patients with more severe hyperglycaemia indicates that this group of patients is particularly at risk of developing deficiency of this vitamin. As ascorbic acid has many important functions in the body, it may be necessary to supplement this vitamin in patients with chronically poorly controlled diabetes. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|