Characteristics of woodchuck hepatitis X-antigen in the livers and sera from infected animals
| Autor: | Marcia M. Clayton, Ling-Xun Duan, Laura Lega, Mark Feitelson |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
Hepatitis
Hepatitis B virus HBsAg Hepatitis X Hepatology biology viruses Woodchuck hepatitis virus Hepatitis B biology.organism_classification medicine.disease medicine.disease_cause Immunohistochemistry Virology Hepatitis B Antigens HBcAg Liver HBeAg Marmota Immunology Trans-Activators medicine Animals Viral Regulatory and Accessory Proteins Viral load |
| Zdroj: | Journal of Hepatology. 17:S24-S34 |
| ISSN: | 0168-8278 |
| DOI: | 10.1016/s0168-8278(05)80420-9 |
| Popis: | This study tests the hypothesis that woodchuck hepatitis virus encoded X-antigen expression correlates with viral replication, with hepatitis, or with both. Paired liver and serum samples from each of 55 infected woodchucks were used. Seven of 8 carriers with high levels of viral DNA in serum also had X-antigen in serum. In contrast, the frequency of X-antigen in serum was low among infected woodchucks that did not have viral surface antigen in the serum. Statistical analysis showed a significant relationship between X-antigen in serum and markers of viral replication. Woodchuck hepatitis X-antigen (WHxAg) expression in liver but not serum of carriers closely correlated with the presence of hepatitis. The finding of X-antigen in the liver of infected animals with hepatitis that cleared the virus surface antigen from serum also suggests that X-antigen is associated with ongoing hepatitis. Hence, the persistence of WHxAg in serum may signal continuing viral replication and, in liver, may contribute to the pathogenesis of chronic infection. |
| Databáze: | OpenAIRE |
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