Induction Immunosuppressive Therapy Use in Deceased Donor Kidney Transplantation: 11-Year Experience in Veracruz, Mexico
Autor: | Gustavo Martínez-Mier, Luis F Budar-Fernández, Sandro F Ávila-Pardo, María Fernanda Trujillo-Martínez, A. Uscanga-Montesano, L.J. Mateu-Rivera, Marco T Méndez-López, Ernesto Soto-Miranda, D. Avila y Falfan |
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Rok vydání: | 2016 |
Předmět: |
Graft Rejection
Male Basiliximab medicine.medical_treatment 030232 urology & nephrology Kaplan-Meier Estimate 030204 cardiovascular system & hematology 0302 clinical medicine Child Kidney transplantation Cause of death education.field_of_study Graft Survival Antibodies Monoclonal Immunosuppression Middle Aged Tissue Donors Child Preschool Creatinine Cyclosporine Female Immunosuppressive Agents medicine.drug Adult medicine.medical_specialty Adolescent Recombinant Fusion Proteins Population Calcineurin Inhibitors Delayed Graft Function 03 medical and health sciences Young Adult medicine Humans education Mexico Dialysis Aged Antilymphocyte Serum Retrospective Studies Immunosuppression Therapy Transplantation Thymoglobulin business.industry medicine.disease Kidney Transplantation Surgery business |
Zdroj: | Transplantation proceedings. 48(2) |
ISSN: | 1873-2623 |
Popis: | Background Induction therapy reduces the frequency of acute rejection and delayed graft function in renal transplantation. Basiliximab and Thymoglobulin are most commonly used agents for induction. Methods A retrospective study of two transplant centers in Veracruz, Mexico compared induction therapy in deceased donor renal transplantation from 2003 to 2014. Efficacy and safety outcomes evaluated were primary graft nonfunction, delayed graft function, acute rejection episodes and hospitalizations during first year, and patient and graft survival. P Results Seventy deceased kidney donors (40 male) were studied. Mean donor age was 32.9 ± 14.3 years, mean donor BMI 25.6 ± 4.3 kg/m2, and mean donor creatinine 1.13 ± 0.58 mg/dL. Main cause of death was trauma (62.9%). In total, 125 kidney transplantations were performed, with female predominance (53.6%) and mean age 33.8 ± 11.8 years. Of these, 66.4% used basiliximab and 33.6% Thymoglobulin. Thymoglobulin patients were significantly older, with lower weight and BMI, and were on dialysis longer than basiliximab patients. DGF was present in 19.3% of basiliximab patients vs 16.7% in Thymoglobulin patients, acute rejection occurred in 16.9% of basiliximab patients vs 19% Thymoglobulin patients. A total of 33.7% basiliximab patients were hospitalized during the first year vs 47.6% Thymoglobulin-induced patients (P > .05). Mean graft survival was 84.2 ± 5.3 months (73.8–94.7) basiliximab vs 32.4 ± 28.7 months (28.7–36.1) Thymoglobulin, Kaplan-Meier survival did not show statistically significant differences between groups (P = .276; CI 95%). Conclusion Similar transplant outcomes were obtained using basiliximab or Thymoglobulin induction in our population. |
Databáze: | OpenAIRE |
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