Role of cathepsin D activation in major adverse cardiovascular events and new-onset heart failure after STEMI

Autor: Ziya Ismailoglu, Ahmet Bacaksiz, Emrah Sevgili, Aylin Hatice Yamac, Sitki Kucukbuzcu, Elif Kilic, Muharrem Nasifov, Huseyin Uyarel, Parviz Jafarov, Cilem Ercan
Rok vydání: 2015
Předmět:
Zdroj: Herz. 40:912-920
ISSN: 1615-6692
0340-9937
DOI: 10.1007/s00059-015-4311-6
Popis: Increased serum levels of the activated aspartic lysosomal endopeptidase cathepsin D (CatD) have been found in patients with acute myocardial infarction (AMI). However, to date there have been no analyses of clinical follow-up data measuring the enzyme course and its role in the development of post-MI heart failure. This study aimed to evaluate the role of serum CatD activity in the development of heart failure in patients with ST-segment elevation acute myocardial infarction (STEMI). Eighty-eight consecutive patients (79.5 % men, mean age 57.4 ± 10.2 years) with STEMI were included in this study. Serum CatD activity was measured directly after primary percutaneous coronary intervention (PCI), before discharge, and at the 6-month follow-up. Patients were monitored for major adverse cardiovascular events (MACE), defined as hospitalization due to cardiovascular causes, recurrent nonfatal myocardial infarction, unplanned PCI, new-onset heart failure, and cardiovascular mortality. Serum CatD activity was significantly higher in patients with AMI after PCI and during follow-up (FU) than that in age-matched controls (16.2 ± 7.5 and 29.8 ± 8.9 vs. 8.5 ± 4.2 RFU; p
Databáze: OpenAIRE
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