Porphyrin-Based Nanomedicines for Cancer Treatment
Autor: | Yuanpei Li, Aaron Lindstrom, Xiangdong Xue |
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Rok vydání: | 2019 |
Předmět: |
Models
Molecular Porphyrins Biomedical Engineering Cancer therapy Pharmaceutical Science Bioengineering Nanotechnology 02 engineering and technology 01 natural sciences Theranostic Nanomedicine chemistry.chemical_compound Neoplasms polycyclic compounds medicine Animals Humans Pharmacology Tomography Emission-Computed Single-Photon medicine.diagnostic_test 010405 organic chemistry Organic Chemistry Optical Imaging Magnetic resonance imaging Hyperthermia Induced Photothermal therapy 021001 nanoscience & nanotechnology Polymeric nanoparticles Porphyrin Magnetic Resonance Imaging 0104 chemical sciences Cancer treatment chemistry Photochemotherapy Positron emission tomography Positron-Emission Tomography Liposomes Nanoparticles 0210 nano-technology Emission computed tomography Biotechnology |
Zdroj: | Bioconjugate chemistry. 30(6) |
ISSN: | 1520-4812 |
Popis: | As unique molecules with both therapeutic and diagnostic properties, porphyrin derivatives have been extensively employed for cancer treatment. Porphyrins not only show powerful phototherapeutic effects (photodynamic and photothermal therapies), but also exhibit excellent imaging capacities, such as near-infrared fluorescent imaging (NIRFI), magnetic resonance imaging (MRI), photoacoustic imaging (PAI), positron emission tomography (PET), and single-photon emission computed tomography (SPECT). In order to take advantage of their robust phototherapeutic effects and excellent imaging capacities, porphyrins can be used to create nanomedicines with effective therapeutic and precise diagnostic properties for cancer treatment. In this Review, we summarize porphyrin-based nanomedicines which have been developed recently, including porphyrin-based liposomes, micelles, polymeric nanoparticles, peptide nanoparticles, and small-molecule nanoassemblies, and their applications on cancer therapy and diagnosis. The outlook and limitation of porphyrin-based nanomedicines are also reviewed. |
Databáze: | OpenAIRE |
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