Macrophages Are Key Regulators of Stem Cells during Skeletal Muscle Regeneration and Diseases
| Autor: | Paul Fabre, Junio Dort, Nicolas A. Dumont, Thomas Molina |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
0303 health sciences
Cell type lcsh:Internal medicine Myogenesis Regeneration (biology) Skeletal muscle Inflammation Cell Biology Review Article Muscle disorder Biology Cell biology 03 medical and health sciences 0302 clinical medicine medicine.anatomical_structure medicine Macrophage medicine.symptom Stem cell lcsh:RC31-1245 Molecular Biology 030217 neurology & neurosurgery 030304 developmental biology |
| Zdroj: | Stem Cells International Stem Cells International, Vol 2019 (2019) |
| ISSN: | 1687-966X |
| Popis: | Muscle regeneration is a closely regulated process that involves a variety of cell types such as satellite cells, myofibers, fibroadipogenic progenitors, endothelial cells, and inflammatory cells. Among these different cell types, macrophages emerged as a central actor coordinating the different cellular interactions and biological processes. Particularly, the transition of macrophages from their proinflammatory to their anti-inflammatory phenotype was shown to regulate inflammation, myogenesis, fibrosis, vascularization, and return to homeostasis. On the other hand, deregulation of macrophage accumulation or polarization in chronic degenerative muscle disorders was shown to impair muscle regeneration. Considering the key roles of macrophages in skeletal muscle, they represent an attractive target for new therapeutic approaches aiming at mitigating various muscle disorders. This review aims at summarizing the novel insights into macrophage heterogeneity, plasticity, and functions in skeletal muscle homeostasis, regeneration, and disease. |
| Databáze: | OpenAIRE |
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