Limited appearance of apocarotenoids is observed in plasma after consumption of tomato juices: a randomized human clinical trial
| Autor: | David M. Francis, Morgan J. Cichon, Earl H. Harrison, Steven J. Schwartz, Jessica L. Cooperstone, Ken M. Riedl, Robert W. Curley, Janet A. Novotny |
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| Rok vydání: | 2018 |
| Předmět: |
Adult
Male 0301 basic medicine Vitamin Receptors Retinoic Acid Nutritional Status Medicine (miscellaneous) High-performance liquid chromatography Retinoids Young Adult 03 medical and health sciences chemistry.chemical_compound Lycopene food Solanum lycopersicum Humans Food science Carotenoid Aged chemistry.chemical_classification Nutrition and Dietetics Cucumber juice Retinol Retinal Middle Aged Postprandial Period beta Carotene Carotenoids food.food Diet Fruit and Vegetable Juices Original Research Communications 030104 developmental biology chemistry Retinaldehyde Apocarotenoid Female Plant Preparations Diterpenes |
| Zdroj: | The American Journal of Clinical Nutrition. 108:784-792 |
| ISSN: | 0002-9165 |
| Popis: | BACKGROUND: Nonvitamin A apocarotenoids occur in foods. Some function as retinoic acid receptor antagonists in vitro, though it is unclear if apocarotenoids are absorbed or accumulate to levels needed to elicit biological function. OBJECTIVE: The aim of this study was to quantify carotenoids and apocarotenoids (β-apo-8′-, -10′-, -12′-, and -14′-carotenal, apo-6′-, -8′-, -10′-, -12′-, and -14′-lycopenal, retinal, acycloretinal, β-apo-13-carotenone, and apo-13-lycopenone) in human plasma after controlled consumption of carotenoid-rich tomato juices. DESIGN: Healthy subjects (n = 35) consumed a low-carotenoid diet for 2 wk, then consumed 360 mL of high-β-carotene tomato juice (30.4 mg of β-carotene, 34.5 μg total β-apocarotenoids/d), high-lycopene tomato juice (42.5 mg of lycopene, 119.2 μg total apolycopenoids/d), or a carotenoid-free control (cucumber juice) per day for 4 wk. Plasma was sampled at baseline (after washout) and after 2 and 4 wk, and analyzed for carotenoids and apocarotenoids using high-pressure liquid chromatography (HPLC) and HPLC-tandem mass spectrometry, respectively. The methods used to analyze the apocarotenoids had limits of detection of ∼ 100 pmol/L. RESULTS: Apocarotenoids are present in tomato juices at 0.1–0.5% of the parent carotenoids. Plasma lycopene and β-carotene increased (P |
| Databáze: | OpenAIRE |
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