Z-ajoene from Crushed Garlic Alleviates Cancer-Induced Skeletal Muscle Atrophy
| Autor: | Mi-Kyung Sung, Ji-Won Heo, Sorim Nam, Sung-Eun Kim, Hye-jin Lee, Jong-Seok Lim, Jae-Ha Ryu, Minson Kweon, A-Reum Kim |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Cachexia lcsh:TX341-641 Muscle Development Protective Agents Article 03 medical and health sciences chemistry.chemical_compound Mice 0302 clinical medicine skeletal muscle atrophy Cell Line Tumor Myokine medicine Myocyte Animals Humans cancer Ajoene Disulfides Protein kinase A STAT3 Garlic Muscle Skeletal Mice Inbred BALB C Nutrition and Dietetics biology Chemistry Myogenesis Plant Extracts digestive oral and skin physiology food and beverages musculoskeletal system Muscle atrophy Cell biology Muscular Atrophy 030104 developmental biology allium sativum 030220 oncology & carcinogenesis Sulfoxides Colonic Neoplasms biology.protein c2c12 cells z-ajoene medicine.symptom Janus kinase Allium sativum lcsh:Nutrition. Foods and food supply Food Science |
| Zdroj: | Nutrients, Vol 11, Iss 11, p 2724 (2019) Nutrients Volume 11 Issue 11 |
| ISSN: | 2072-6643 |
| Popis: | Skeletal muscle atrophy is one of the major symptoms of cancer cachexia. Garlic (Allium sativum), one of the world&rsquo s most commonly used and versatile herbs, has been employed for the prevention and treatment of diverse diseases for centuries. In the present study, we found that ajoene, a sulfur compound found in crushed garlic, exhibits protective effects against muscle atrophy. Using CT26 tumor-bearing BALB/c mice, we demonstrate in vivo that ajoene extract alleviated muscle degradation by decreasing not only myokines secretion but also janus kinase/signal transducer and activator of transcription 3 (JAK/STAT3) and SMADs/forkhead box (FoxO) signaling pathways, thereby suppressing muscle-specific E3 ligases. In mouse skeletal myoblasts, Z-ajoene enhanced myogenesis as evidenced by increased expression of myogenic markers via p38 mitogen-activated protein kinase (MAPK) activation. In mature myotubes, Z-ajoene protected against muscle protein degradation induced by conditioned media from CT26 colon carcinoma cells, by suppressing expression of muscle specific E3 ligases and nuclear transcription factor kappa B (NF-&kappa B) phosphorylation which contribute to muscle atrophy. Moreover, Z-ajoene treatment improved myofiber formation via stimulation of muscle protein synthesis. These findings suggest that ajoene extract and Z-ajoene can attenuate skeletal muscle atrophy induced by cancer cachexia through suppressing inflammatory responses and the muscle wasting as well as by promoting muscle protein synthesis. |
| Databáze: | OpenAIRE |
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