Identification of the Factors Associated With Intraperitoneal Pressure in ADPKD Patients Treated With Peritoneal Dialysis
| Autor: | Malika Pierre, Moustapha Dramé, Andréea Petrache, Mickael Sigogne, Caroline E Mora, Michel Fischbach, Lukshe Kanagaratnam, Fatouma Touré, Claude Marcus |
|---|---|
| Přispěvatelé: | Université d'Angers (UA), Service Néphrologie [CH Le Mans], Centre Hospitalier Le Mans (CH Le Mans), Matrice extracellulaire et dynamique cellulaire - UMR 7369 (MEDyC), Université de Reims Champagne-Ardenne (URCA)-SFR CAP Santé (Champagne-Ardenne Picardie Santé), Université de Reims Champagne-Ardenne (URCA)-Université de Picardie Jules Verne (UPJV)-Université de Reims Champagne-Ardenne (URCA)-Université de Picardie Jules Verne (UPJV)-Centre National de la Recherche Scientifique (CNRS) |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
medicine.medical_treatment [SDV]Life Sciences [q-bio] Population 030232 urology & nephrology Autosomal dominant polycystic kidney disease Urology Kidney Volume Abdominal cavity 030204 cardiovascular system & hematology lcsh:RC870-923 intraperitoneal pressure Peritoneal dialysis 03 medical and health sciences 0302 clinical medicine Clinical Research medicine 10. No inequality education Dialysis ADPKD 2. Zero hunger Body surface area education.field_of_study Univariate analysis business.industry lcsh:Diseases of the genitourinary system. Urology medicine.disease 3. Good health medicine.anatomical_structure peritoneal dialysis Nephrology business |
| Zdroj: | Kidney International Reports Kidney International Reports, Elsevier, 2020, 5, pp.1007-1013. ⟨10.1016/j.ekir.2020.04.012⟩ Kidney International Reports, Vol 5, Iss 7, Pp 1007-1013 (2020) |
| ISSN: | 2468-0249 |
| Popis: | Introduction Peritoneal dialysis (PD) is reported to be underused in the autosomal dominant polycystic kidney disease (ADPKD) population because doctors fear technical failure caused by reduced abdominal space and high intraperitoneal pressure (IPP). Methods We designed a multicenter retrospective study to be carried out in 15 French centers recruiting 60 patients with ADPKD treated with PD to identify factors associated with IPP. Inclusion criteria were start of PD between 2010 and 2017, available tomodensitometry, and IPP measurement in the first year of dialysis. The clinical and radiological data for each patient were reviewed by the same operator. Total kidney volume (TKV), liver volume, and the volume of the abdominal cavity were measured using contouring. Results TKV and the volume of the abdominal cavity in women and men were, respectively, 2397 ml versus 3758 ml and 9402 ml versus 12,920 ml. In the univariate analysis, IPP was significantly and positively associated with body surface area (P = 0.0024), body mass index (BMI) (P < 0.0001), the volume of the abdominal cavity (P = 0.0005), and the volume of the dialysate infused in the peritoneal cavity (IPV) (P = 0.0108). In the multivariate analysis, only BMI was still significantly associated with IPP (P = 0.0004) Conclusions Our results identified BMI as the main factor linked to IPP in patients with ADPKD. Despite a reliable assessment of the volume of their organs we did not find any correlation between liver and kidney volumes and IPP. To our knowledge, this is the first study designed to identify factors associated with IPP in patients with ADPKD on PD. Graphical abstract |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|