Influence of human leukocyte antigen mismatching on rejection development and allograft survival in liver transplantation: Is the relevance of HLA-A locus matching being underestimated?
| Autor: | María R. Moya-Quiles, José A. Campillo, Alexandre Bosch, Carmen Botella, Alfredo Minguela, Francisco Boix, Gema Salgado, Luis Marín, M.R. Lopez-Alvarez, Manuel Miras, Jesús de la Peña-Moral, Ruth López-Hernández, Manuel Muro, María R. Álvarez-López, Francisco Sánchez-Bueno, Jose Miguel Bolarín, Noelia Pérez, Pedro Gil Martínez, Ricardo Robles, Helios Martínez, Ana M. García-Alonso |
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| Rok vydání: | 2012 |
| Předmět: |
Adult
Graft Rejection Male Oncology medicine.medical_specialty medicine.medical_treatment Immunology Histocompatibility Testing Human leukocyte antigen Liver transplantation Risk Factors Internal medicine Humans Transplantation Homologous Immunology and Allergy Medicine Adverse effect Retrospective Studies Transplantation HLA-A Antigens Proportional hazards model business.industry Graft Survival Retrospective cohort study HLA-DR Antigens Middle Aged Liver Transplantation HLA-A surgical procedures operative Genetic Loci HLA-B Antigens Female business |
| Zdroj: | Transplant Immunology. 26:88-93 |
| ISSN: | 0966-3274 |
| Popis: | The influence of HLA matching on liver transplant is still controversial, as studies have failed to demonstrate an adverse effect of HLA mismatching on transplant outcome. We examined the effect of HLA mismatching on transplant outcome in a series of 342 consecutive liver transplants (224 finally analyzed). HLA typing was performed by serological and molecular methods. HLA-A matching was associated with an increased chronic rejection incidence (P=0.04). Indeed, HLA-A match also demonstrated a significant impact on allograft survival (P=0.03), confirming previous observation concerning to rejection, as complete HLA-A mismatching favored a better liver transplant outcome. Analysis of HLA-A+B+DR matching also demonstrated a significant impact on graft survival (P |
| Databáze: | OpenAIRE |
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