Umbilical cord blood and neonatal endothelin-1 levels in preterm newborns with and without respiratory distress syndrome

Autor: Rita de Cássia dos Santos Silveira, Ana Claudia Weber Benjamin, Renato S. Procianoy
Rok vydání: 2005
Předmět:
Hyaline membrane disease
Hipertensão pulmonar
Physiology
medicine.medical_treatment
Biochemistry
Gastroenterology
Umbilical cord
General Pharmacology
Toxicology and Pharmaceutics
lcsh:QH301-705.5
lcsh:R5-920
Respiratory distress
Endothelin-1
General Neuroscience
General Medicine
Fetal Blood
medicine.anatomical_structure
Anesthesia
Gestation
Female
Analysis of variance
Prematurity
lcsh:Medicine (General)
Infant
Premature
medicine.medical_specialty
Síndrome do desconforto respiratório do recém-nascido
Respiratory distress syndrome
Immunology
Biophysics
SNAPPE II
Enzyme-Linked Immunosorbent Assay
Pulmonary hypertension
Internal medicine
medicine
Humans
Endotelina-1
Prematuridade
Mechanical ventilation
Analysis of Variance
Respiratory Distress Syndrome
Newborn
business.industry
Case-control study
Infant
Newborn
Cell Biology
medicine.disease
Endothelin 1
lcsh:Biology (General)
Case-Control Studies
business
Biomarkers
Zdroj: Brazilian Journal of Medical and Biological Research, Vol 38, Iss 9, Pp 1417-1422 (2005)
Repositório Institucional da UFRGS
Universidade Federal do Rio Grande do Sul (UFRGS)
instacron:UFRGS
Brazilian Journal of Medical and Biological Research v.38 n.9 2005
Brazilian Journal of Medical and Biological Research
Associação Brasileira de Divulgação Científica (ABDC)
instacron:ABDC
Brazilian Journal of Medical and Biological Research, Volume: 38, Issue: 9, Pages: 1417-1422, Published: SEP 2005
ISSN: 0100-879X
Popis: Increased pulmonary vascular resistance in preterm newborn infants with respiratory distress syndrome is suggested, and endothelin-1 plays an important role in pulmonary vascular reactivity in newborns. We determined umbilical cord blood and neonatal (second sample) levels of endothelin-1 in 18 preterm newborns with respiratory distress syndrome who had no clinical or echocardiographic diagnosis of pulmonary hypertension and 22 without respiratory distress syndrome (gestational ages: 31.4 +/- 1.6 and 29.3 +/- 2.3 weeks, respectively). Umbilical cord blood and a second blood sample taken 18 to 40 h after birth were used for endothelin-1 determination by enzyme immunoassay. Median umbilical cord blood endothelin-1 levels were similar in both groups (control: 10.9 and respiratory distress syndrome: 11.4 pg/mL) and were significantly higher than in the second sample (control: 1.7 pg/mL and respiratory distress syndrome: 3.5 pg/mL, P < 0.001 for both groups). Median endothelin-1 levels in the second sample were significantly higher in children with respiratory distress syndrome than in control infants (P < 0.001). There were significant positive correlations between second sample endothelin-1 and Score for Neonatal Acute Physiology and Perinatal Extension II (r = 0.36, P = 0.02), and duration of mechanical ventilation (r = 0.64, P = 0.02). A slower decline of endothelin-1 from birth to 40 h of life was observed in newborns with respiratory distress syndrome when compared to controls. A significant correlation between neonatal endothelin-1 levels and some illness-severity signs suggests that endothelin-1 plays a role in the natural course of respiratory distress syndrome in preterm newborns.
Databáze: OpenAIRE
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